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IL15 — KLRC1

Text-mined interactions from Literome

Roberts et al., J Immunol 2001 : Expression and function of NKG2D are selectively up-regulated by the cytokine IL-15 , which is released by the inflamed intestinal epithelium ... Uncontrolled secretion of IL-15 could lead to excessive induction of NKG2D and thus contribute to the development of autoimmune disease by facilitating the activation of autoreactive T cells
Sutherland et al., J Immunol 2002 (MAP Kinase Signaling System) : In this study we show that NKG2D is the ULBP counterstructure on primary NK cells and that its expression is up-regulated by IL-15 stimulation
Derre et al., J Immunol 2002 (Melanoma) : We show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8 ( + ) T cells in culture, and that this induction was mediated neither by IFN-gamma nor by IL-15
Groh et al., Proc Natl Acad Sci U S A 2003 (Arthritis, Rheumatoid) : NKG2D was induced by tumor necrosis factor alpha and IL-15 , which are abundant in inflamed synovia and RA patient sera
Koning et al., Springer Semin Immunopathol 2005 (Celiac Disease...) : Simultaneously, gluten exposure leads to increased production of IL15 , which induces the expression of NKG2D on intraepithelial lymphocytes and its ligand MICA on epithelial cells, leading to epithelial cell destruction
Dann et al., J Infect Dis 2005 (Cryptosporidiosis) : Furthermore, flow cytometry revealed that IL-15 increased expression of the activation receptor NKG2D on NK cells, particularly among the CD16Hi cytolytically active cells
Zhang et al., Cytokine 2008 : NKG2D or MICA blockade attenuated the up-regulation of IL-15 on NK cytolysis, demonstrating that the up-regulatory effect of IL-15 on NK cytolysis is at least partly dependent of the interaction of NKG2D and MICA
Ye et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008 (Breast Neoplasms) : IL-15 up-regulated the expression of NKG2D on NK cells and increased NK cells cytotoxicity to breast cancer cells
Huang et al., Oncol Rep 2010 : Up-regulation of NKG2F receptor, a functionally unknown killer receptor, of human natural killer cells by interleukin-2 and interleukin-15
Sène et al., PLoS Pathog 2010 (Hepatitis C, Chronic...) : Exogenous IL-15 can antagonize the TGFß effect and restore normal NKG2D expression on NK cells
Zhou et al., PloS one 2012 : In addition, IL-15 , IL-18, and IFN-ß secreted by poly I:C treated macrophages are also involved in NKG2D expression and NK cell activation
Hromadnikova et al., Mediators Inflamm 2013 : Using flow cytometry the effect of in vitro stimulation with IL-2 or IL-15 alone or in combination with Hsp70 derived 14-mer peptide ( TKD ) on cell surface expression of NK activatory receptors ( CD16, NKG2D, NKG2C , NKp46, NKp44, NKp30, KIR2DL4, DNAM-1, and LAMP1 ) and NK inhibitory receptors ( NKG2A, KIR2DL2/L3, LIR1/ILT-2, and NKR-P1A ) in healthy individuals was studied
Pahl et al., Cancer Immunol Immunother 2013 (Osteosarcoma...) : The 40 h coculture of NK cells with sarcoma cells reversibly interfered with the IL15 induced expression of NKG2D , DNAM-1 and NKp30 and inhibited the cytolytic activity of NK cells
Zdrenghea et al., Med Hypotheses 2013 : IL-15 increases expression of NKG2D and its ligands and can increase natural killer cell mediated cytotoxicity against tumour cells