UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to SMAD3

SMAD3 — VDR

Pathways - manually collected, often from reviews:

NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: VDR (VDR) → SMAD3/SMAD4 complex (SMAD3-SMAD4) (modification, collaborate)
Yanagisawa et al., Science 1999, Dennler et al., Oncogene 2005
Evidence: mutant phenotype, reporter gene, physical interaction
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: VDR (VDR) → SMAD3/SMAD4/VDR complex (SMAD3-SMAD4-VDR) (modification, collaborate)
Yanagisawa et al., Science 1999, Dennler et al., Oncogene 2005
Evidence: mutant phenotype, reporter gene, physical interaction
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SMAD3/SMAD4 complex (SMAD3-SMAD4) → SMAD3/SMAD4/VDR complex (SMAD3-SMAD4-VDR) (modification, collaborate)
Yanagisawa et al., Science 1999, Dennler et al., Oncogene 2005
Evidence: mutant phenotype, reporter gene, physical interaction
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: Cbp/p300/Src-1 complex (EP300_CREBBP-NCOA1) → SMAD3/SMAD4/VDR complex (SMAD3-SMAD4-VDR) (modification, activates)
Yanagisawa et al., Science 1999, Dennler et al., Oncogene 2005
Evidence: mutant phenotype, reporter gene, physical interaction
WikiPathways Ovarian Infertility Genes: SMAD3 → PGR/ESR2/VDR/NR5A1/TBP/NCOR1/NRIP1/EGR1/CEBPB (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Bind Interaction: SMAD3 — VDR Leong et al., J Biol Chem 2001 *
IRef Bind_translation Interaction: SMAD3 — VDR (affinity chromatography technology) Leong et al., J Biol Chem 2001 *
IRef Biogrid Interaction: VDR — SMAD3 (direct interaction, pull down) Yanagisawa et al., Science 1999
IRef Biogrid Interaction: VDR — SMAD3 (direct interaction, two hybrid) Yanagisawa et al., Science 1999
IRef Hprd Interaction: VDR — SMAD3 (in vivo) Yanagisawa et al., Science 1999
IRef Hprd Interaction: VDR — SMAD3 (in vitro) Yanagisawa et al., Science 1999
IRef Intact Interaction: SMAD3 — VDR (physical association, pull down) Leong et al., J Biol Chem 2001 *
IRef Ophid Interaction: SMAD3 — VDR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005