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PRKCA — SPP1
Text-mined interactions from Literome
Meacci et al., FEBS Lett 1999
:
SPP increased membrane association of
PKCalpha , PKCdelta and PKClambda, however, only PKCalpha and PKCdelta played a role in PLD activation since low concentrations of GF109203X and rottlerin, a selective inhibitor of PKCdelta, prevented PLD stimulation
Meacci et al., FEBS Lett 2000
:
Conversely rottlerin, a selective inhibitor of PKC delta, was without effect, demonstrating that
SPP signaling to Rho A
involves PKC alpha but not PKC delta activation