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PRKAR2A — S100A12

Text-mined interactions from Literome

Sun et al., J Neurophysiol 2004 (Hyperalgesia...) : These results are consistent with the hypothesis that CGRP produces hyperalgesia by a direct action on CGRP1 receptors in the spinal cord dorsal horn and suggest that the effects of CGRP are mediated by both PKA and PKC second-messenger pathways
Villa et al., Am J Physiol Cell Physiol 2006 (Femoral Fractures) : CGRP ( 10 ( -8 ) M ) enhanced protein kinase A (PKA) activity in hOB, and hOB exposure to the PKA inhibitor, H89 ( 2 x 10 ( -6 ) M ), abolished the inhibitory effect of CGRP on OPG secretion
Yue et al., Eur J Pharmacol 2008 : The selective PKA inhibitor, H-89, attenuates the sustained morphine mediated augmentation of basal CGRP release, indicating that the cAMP/PKA pathway plays an important role in regulation of CGRP release from sensory neurons
Tumati et al., Neuroreport 2009 (Hyperalgesia...) : Sustained cannabinoid agonist treatment augments CGRP release in a PKA dependent manner
Zhong et al., Am J Physiol Regul Integr Comp Physiol 2009 (Disease Models, Animal...) : CGRP ( 8-37 ), a selective CGRP receptor antagonist, RP67580, a selective neurokinin-1 receptor antagonist, PKC-epsilon V1-2, a selective PKC-epsilon inhibitor, or H-89, a selective PKA inhibitor , abolished SLIGRL protection by inhibiting the recovery of the rate of coronary flow, maximum rate of left ventricular pressure development, and left ventricular developed pressure, and increasing left ventricular end-diastolic pressure in WT but not TRPV1 ( -/- ) hearts
Tumati et al., Eur J Pharmacol 2010 (Pain) : In the present work we investigated the hypothesis that morphine pretreatment also sensitizes ACs toward Gs-protein coupled excitatory modulators ( such as PGE2 ), leading to augmented PKA dependent CGRP release from PGE2 stimulated primary sensory dorsal root ganglion ( DRG ) neurons ... Our results show that sustained morphine treatment potentiated PGE2 mediated cAMP formation and augmented PGE2 evoked CGRP release from cultured primary sensory neurons in a PKA dependent manner
Wang et al., Exp Neurol 2013 : Involvement of PKA dependent upregulation of nNOS-CGRP in adrenomedullin initiated mechanistic pathway underlying CFA induced response in rats
Van der Kloot et al., J Physiol 1998 : ( In other preparations CGRP also activates PKA . )