◀ Back to RPTOR
FOXO1 — RPTOR
Text-mined interactions from Literome
Southgate et al., J Biol Chem 2007
:
FOXO1 regulates the expression of 4E-BP1 and
inhibits mTOR signaling in mammalian skeletal muscle ... Using C2C12 mouse myoblasts that stably express inducible FOXO1-ER fusion proteins and transgenic mice that specifically overexpress constitutively active FOXO1 in skeletal muscle ( FOXO ( ++/+ ) ), we show that
FOXO1 inhibits
mTOR signaling and protein synthesis
Chen et al., Dev Cell 2010
:
Activated
FoxO1 inhibits
mTORC1 by TSC2 dependent and TSC2 independent mechanisms ... Thus, under stress conditions,
FoxO inhibits the anabolic activity of
mTORC1 , a major consumer of cellular energy, while activating Akt, which increases cellular energy metabolism, thereby maintaining cellular energy homeostasis
Melnik et al., Exp Dermatol 2013
:
This hypothesis postulates that antiacne agents either enhance nuclear
FoxO activity or
inhibit mTORC1