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NOS1 — PTK2
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Mishra et al., Neurosci Lett 2004
(Hypoxia, Brain) :
The present study tests the hypothesis that hypoxia results in increased protein tyrosine kinase activity in cortical cell membranes of newborn piglets and that the inhibition of
neuronal NOS by administration of 7-nitroindazole sodium salt ( 7-NINA ), a selective inhibitor of nitric oxide synthase (NOS), will
prevent the hypoxia induced increase in
protein tyrosine kinase activity
Rodriguez et al., Anim Reprod Sci 2005
:
These results indicate that NO* may be generated by a sperm
NOS during heparin induced capacitation and that exogenous NO* acts as a capacitation inducer and
involves the participation of PKA, PKC and
PTK as part of the intracellular mechanisms that lead to capacitation in cryopreserved bull spermatozoa
Bhatt et al., Mol Immunol 2010
:
Protein kinase Cdelta and
protein tyrosine kinase regulate peptidoglycan induced nuclear factor-kappaB activation and inducible
nitric oxide synthase expression in mouse peritoneal macrophages in vitro
Geng et al., J Cell Physiol 1995
(Second Messenger Systems) :
The
protein tyrosine kinase ( PTK ) inhibitors herbimycin A or genistein
reduced IL-1 or LPS induced NO release and
NOS enzymatic activity
Miller et al., Am J Physiol 1997
:
The specific protein tyrosine kinase inhibitor genistein was used to determine if
NOS induction is
dependent on
protein tyrosine kinase activation ... Genistein also impaired TNF-alpha induced NOS mRNA accumulation, suggesting
protein tyrosine kinase regulation of
NOS induction occurred at the level of transcription-translation ... The commonality of genistein inhibition suggests that
protein tyrosine kinase activity is
critical for
NOS induction by a variety of stimuli