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GDNF — PTK2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PTK2 → Complex of GDNF-NCAM1 (increases, GDNF/NCAM1 Activity)
  Evidence: Carlos Ibanez and collaborators demonstrated that neural cell adhesion molecule (NCAM) functions as an alternative signaling receptor for GFLs (fig. 2). In the presence of GFR-a, GDNF binds with high affinity to p140-NCAM and intracellularly activates the Src-like kinase c-Fyn and the focal adhesion kinase FAK [29].
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → FAK (PTK2) (modification, activates) Murakami et al., Oncogene 1999, Panta et al., Surgery 2004*, Panta et al., Surgery 2005
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Hisaoka et al., J Pharmacol Exp Ther 2007 : Taken together, these findings indicate that ERK activation through PTK regulates antidepressant induced GDNF production and that the GDNF production in glial cells may be a novel action of the antidepressant, which is independent of monoamine
Hisaoka et al., Nihon Shinkei Seishin Yakurigaku Zasshi 2007 : We reported that total GDNF levels in whole blood in patients with mood disorders were significantly lower than those in healthy control subjects ( Takebayashi et al, 2006 ), and antidepressants increased GDNF production through monoamine independent activation of protein tyrosine kinase ( PTK ) and extracellular signal regulated kinase ( ERK ) in glial cells ( Hisaoka et al, 2007 )
Jing et al., Cell 1996 : GDNF induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF