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CAPN2 — GAP43

Text-mined interactions from Literome

Zakharov et al., Biochemistry (Mosc) 2005 : In addition, calmodulin binding to GAP-43 decreases the rate of calpain mediated GAP-43 proteolysis ... Our results indicate that m-calpain mediated GAP-43 proteolysis regulated by PKC and calmodulin is of physiological relevance, particularly in axonal growth cone guidance
Zakharov et al., J Neurochem 2007 : M-calpain mediated cleavage of GAP-43 near Ser41 is negatively regulated by protein kinase C, calmodulin and calpain inhibiting fragment GAP-43-3 ... A GAP-43 fragment, lacking about forty N-terminal residues ( named GAP-43-3 ), was produced by m-calpain mediated cleavage of GAP-43 and inhibited m-calpain , but not micro-calpain ... A GAP-43 fragment, lacking about forty N-terminal residues ( named GAP-43-3 ), was produced by m-calpain mediated cleavage of GAP-43 and inhibited m-calpain , but not micro-calpain ... GAP-43-3 also blocked m-calpain activity against casein, a model calpain substrate ... This implies that GAP-43-3 , which is present in axon terminals in high amount, can play important role in regulation of m-calpain activity in neurons