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CASP8 — CSE

Text-mined interactions from Literome

Onoue et al., Eur J Biochem 2004 (Pulmonary Disease, Chronic Obstructive) : VIP, at 10 ( -7 ) m, reduced CSE stimulated MMP activity and caspase-3 activation
Raveendran et al., FEBS Lett 2005 : Specific inhibitors of p38 MAP or SAPK/JNK reduced CSE induced caspase activation
Stringer et al., Am J Physiol Lung Cell Mol Physiol 2007 (Pulmonary Disease, Chronic Obstructive) : Consistent with this, CSE inhibited active recombinant caspase-3 activity, which was abolished by dithiothreitol, suggesting a redox-sensitive mechanism ... CSE induced suppression of caspase-3 activity did not alter spontaneous apoptosis but did impair phagocytic activity ... CSE reduced caspase-3 activity in a concentration dependent manner ... These data demonstrate that CSE does not suppress caspase-3 activity below a threshold level to prevent spontaneous apoptosis, but the level of inhibition is sufficient to impair neutrophil phagocytic activity
Kim et al., Autophagy 2008 (Necrosis...) : Reduction of Beclin 1 levels with beclin 1 siRNA inhibited DISC formation and caspase-3/8 activation in response to CSE
Kim et al., Am J Physiol Lung Cell Mol Physiol 2012 : In lung fibroblasts exposed to cigarette smoke extract (CSE), MSC-CM, not only inhibited apoptotic death, but also induced cell proliferation and reversed CSE induced changes in the levels of caspase-3 , p53, p21, p27, Akt, and p-Akt