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RPA1 — XRCC6
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
MIPS CORUM 53BP1-containing complex:
53BP1-containing complex complex (RPA1-RPA2-TP53BP1-XRCC5-XRCC6)
Yoo et al., Oncogene 2005*
-
IRef Corum Interaction:
Complex of 11 proteins
(association, anti tag coimmunoprecipitation)
Yoo et al., Oncogene 2005*
-
IRef Intact Interaction:
Complex of 12 proteins
(association, pull down)
Kanno et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of 117 proteins
(association, tandem affinity purification)
Zhao et al., Journal of proteomics 2011
-
IRef Intact Interaction:
Complex of 400 proteins
(association, cross-linking study)
Humphries et al., Science signaling 2009
-
STRING interaction:
XRCC6
—
RPA1
(interaction, mapped from grid)
-
STRING interaction:
RPA1
—
XRCC6
(interaction, mapped from grid)
Text-mined interactions from Literome
Iftode et al., Crit Rev Biochem Mol Biol 1999
:
RPA is a phosphorylation
target for
DNA dependent protein kinase (DNA-PK) and likely the ataxia telangiectasia mutated gene (ATM) protein kinase, and recent observations are described that suggest that RPA phosphorylation plays a significant modulatory role in the cellular response to DNA damage
Block et al., Nucleic Acids Res 2004
:
However, the relative
roles of ATM and
DNA-PK in the site-specific DNA damage induced phosphorylation of
RPA32 have not been reported
Liu et al., Nucleic Acids Res 2012
:
Distinct
roles for
DNA-PK , ATM and ATR in
RPA phosphorylation and checkpoint activation in response to replication stress
Brush et al., Proc Natl Acad Sci U S A 1994
:
Studies with the simian virus 40 model system indicate that
DNA-PK is
required for DNA-replication dependent
RPA phosphorylation