Gene interactions and pathways from curated databases and text-mining

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PRKAR1A — YWHAB

Text-mined interactions from Literome

MacNicol et al., J Biol Chem 1999 : The kinase domains of Raf-1 and B-Raf are highly conserved, and it has been predicted that B-Raf catalytic activity would also be inhibited by PKA
Calipel et al., J Biol Chem 2006 (Cell Transformation, Neoplastic...) : Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity, ERK1/2 activation, and cell proliferation in ( WT ) B-Raf cells, whereas it did not affect ( V600E ) B-Raf cells, demonstrating a key role of PKA in mediating ( WT ) B-Raf/ERK signaling for uveal melanoma cell growth ... This ruled out a role for Rap1 in the PKA mediated B-Raf/ERK activation in ( WT ) B-Raf cells
Peraldi et al., FEBS Lett 1995 : Hence, these data indicate that the PKA mediated phosphorylation of B-Raf hampers its interaction with p21ras, which is responsible for the PKA mediated decrease in B-Raf activity