UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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HSP90AA1 — PRKAR1A

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Intact Interaction: Complex of 27 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
IRef Intact Interaction: Complex of 23 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013

Text-mined interactions from Literome

Shapiro et al., Curr Biol 2009 (Candidiasis) : Hsp90 regulates morphogenetic circuitry by repressing Ras1-PKA signaling
Shapiro et al., PloS one 2012 : Sgt1 physically interacts with Cyr1, and depletion of either Sgt1 or Hsp90 activates cAMP-PKA signaling, revealing the elusive link between Hsp90 and the PKA signaling cascade