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PDK1 — SRC

Text-mined interactions from Literome

Grillo et al., Eur J Biochem 2000 : An inhibitor of Src kinase ( PP2 ) decreased the peroxovanadate induced PDK1 tyrosine phosphorylation and overexpression of v-Src stimulated this phosphorylation
Kim et al., Mol Endocrinol 2003 (Carcinoma, Papillary...) : Moreover, Y9 phosphorylation of PDK1 by RET/PTC does not require phosphatidylinositol 3-kinase or Src activity
Taniyama et al., Mol Cell Biol 2003 : We found that angiotensin II stimulates the tyrosine phosphorylation of PDK1 in vascular smooth muscle in a calcium- and c-Src dependent manner ... The calcium activated tyrosine kinase Pyk2 acts as a scaffold for Src dependent phosphorylation of PDK1 on Tyr9, which permits phosphorylation of Tyr373 and -376 by Src
Block et al., J Biol Chem 2008 (Fibrosis...) : Nox4 NAD ( P ) H oxidase mediates Src dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II : role in mesangial cell hypertrophy and fibronectin expression ... This work provides the first evidence that Nox4 derived ROS are responsible for Ang II-induced PDK-1 tyrosine phosphorylation and activation through stimulation of Src
Kurata et al., Cancer Sci 2008 : To identify novel regulators of PDK1, we performed E. coli based two-hybrid screening and revealed that tumor suppressor candidate 4 (TUSC4), also known as nitrogen permease regulator-like 2 ( NPRL2 ), formed a complex with PDK1 and suppressed Src dependent tyrosine phosphorylation and activation of PDK1 in vitro and in cells