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FLT1 — NOTCH1

Text-mined interactions from Literome

Zaghloul et al., Int J Oncol 2009 (Neovascularization, Pathologic...) : DC101 treatment elicited increased : 1 ) expression of VEGFR1 and its ligand placental growth factor ; and 2 ) increased Notch activation in tumor vasculature concurrent with expression of the Notch ligand Jagged1
Funahashi et al., Journal of angiogenesis research 2010 : We show that ectopic expression of activated Notch1 induces endothelial morphogenesis in human umbilical vein endothelial cells ( HUVEC ) in a VEGFR-1 dependent manner ... Notch1 mediated upregulation of VEGFR-1 in HUVEC increased their responsiveness to the VEGFR-1 specific ligand, Placental Growth Factor (PlGF) ... In mice and human endothelial cells, inhibition of Notch signaling resulted in decreased VEGFR-1 expression during VEGF-A induced neovascularization
Outtz et al., J Immunol 2010 (Inflammation) : Thus, both pharmacological inhibition of Notch and genetic analysis demonstrate that Notch1 regulates VEGFR-1 and cytokine expression in macrophages ... Thus, both pharmacological inhibition of Notch and genetic analysis demonstrate that Notch1 regulates VEGFR-1 and cytokine expression in macrophages
Krueger et al., Development 2011 : Thus, Flt1 acts in a Notch dependent manner as a negative regulator of tip cell differentiation and branching