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IL4 — TCF21

Text-mined interactions from Literome

Dickensheets et al., J Leukoc Biol 1999 : In this overview, we discuss the role of the transcription factor , STAT6 ( signal transducer and activator of transcription-6 ) in mediating IL-4- and IL-13 induced gene expression in monocytes
Dickensheets et al., Proc Natl Acad Sci U S A 1999 (Translocation, Genetic) : IL-4 activates gene expression by inducing tyrosine phosphorylation, homodimerization, and nuclear translocation of the latent transcription factor , STAT6 ( signal transducer and activator of transcription-6 )
Gingras et al., Endocrinology 1999 (Colonic Neoplasms...) : Stat6 is recognized as the principal transcription factor mediating the effects of IL-4
Lagadic-Gossmann et al., Cell Biol Toxicol 2000 (Carcinoma, Hepatocellular...) : As expected, IL-4 induced tyrosine phosphorylation of the STAT6 transcription factor , an effect prevented by the tyrosine kinase inhibitor tyrphostin A25
Abu-Amer et al., J Clin Invest 2001 : To address this issue, this study examined whether IL-4 induced STAT6 transcription factor blocks NF-kappaB transactivation
Madden et al., J Immunol 2002 : Binding of IL-4 by either the type 1 or 2 IL-4R , or of IL-13 by the type 2 IL-4R, initiates Jak dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor , STAT6
Lee et al., Am J Physiol Heart Circ Physiol 2003 : In addition, IL-4 dramatically increased the transcription factor signal transducers and activators of transcription 1 ( STAT1 ) DNA binding activity, an effect that was attenuated by PDTC
McDermott et al., Trends Mol Med 2002 (Familial Mediterranean Fever...) : Disorders of interleukin-1 processing and of regulation of nuclear factor kappaB transcription factor , and possibly defective apoptosis, might be involved in the pathogenesis of all but one of these disorders
Sheikh et al., Hepatology 2008 (Hepatitis C...) : This transcription factor plays a key role in the expression of cytokines, tumor necrosis factor alpha (TNF-alpha), interleukin 6, interleukin 8, tumor growth factor beta, and Fas ligand
Newton et al., J Neuroimmune Pharmacol 2009 (Legionnaires' Disease) : The GATA-3 transcription factor is necessary for IL-4 production and is selectively expressed in Th2 cells
Chen et al., Immunity 2008 (Arthritis, Rheumatoid...) : IRF-4 binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor
Saraiva et al., Immunity 2009 : Interleukin-10 production by Th1 cells requires interleukin-12 induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
Kashiwada et al., Proc Natl Acad Sci U S A 2010 : IL-4 induced transcription factor NFIL3/E4BP4 controls IgE class switching
Trinh et al., Arch Pharm Res 2009 (Pruritus) : These curcuminoids also inhibited degranulation, protein expression of TNF-alpha and IL-4 , and transcription factor NF-kappaB activation in IAC induced RBL-2H3 cells
Ahlfors et al., Blood 2010 : Special AT-rich binding protein 1 ( SATB1 ) is a global chromatin organizer and a transcription factor regulated by interleukin-4 (IL-4) during the early T helper 2 ( Th2 ) cell differentiation
El Chartouni et al., Immunobiology 2010 : IL-4 signaling in macrophages is primarily mediated by the transcription factor signal transducer and activator of transcription 6 ( Stat6 ), which in turn regulates a number of secondary DNA binding proteins that may participate in shaping the resulting phenotype
Elo et al., Immunity 2010 : Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming
Steele et al., Blood 2010 (Leukemia, Lymphocytic, Chronic, B-Cell) : IL-4 induced the rapid phosphorylation and activation of the signal transducer and activator of transcription 6 transcription factor in CLL cells in vitro
Hou et al., Science 1994 : An interleukin-4 induced transcription factor : IL-4 Stat
Köhler et al., Eur J Immunol 1993 (Hypersensitivity) : Allergy associated I epsilon and Ec epsilon receptor II ( CD23b ) genes activated via binding of an interleukin-4 induced transcription factor to a novel responsive element ... Here we report on a novel human transcription factor , termed nuclear factor IL-4 ( NF-IL4 ), which is posttranslationally activated by IL-4 in lymphoid and monocytic cells
Sung et al., J Biol Chem 1993 : Stimulation of interleukin-1 gene transcription may be caused by the stimulation of transcription factor activities, including those of AP-1, by these protein phosphatase inhibitors
Kaplan et al., Immunity 1996 : We have generated Stat6-deficient mice by gene targeting in embryonic stem cells to determine the role of this transcription factor in mediating the biologic functions of IL-4
Palmer-Crocker et al., J Clin Invest 1996 : Furthermore, both IL-4 and IL-13 induce binding of the Stat6 transcription factor to a consensus sequence oligonucleotide
Dent et al., Proc Natl Acad Sci U S A 1998 (Inflammation) : An important signaling pathway for the differentiation of T helper type 2 ( TH2 ) cells from uncommitted CD4 T cell precursors is activation of the STAT6 transcription factor by interleukin 4 (IL-4)
Ho et al., J Exp Med 1998 : The c-maf protooncogene is a T helper cell type 2 ( Th2 ) -specific transcription factor that activates the interleukin (IL)-4 promoter in vitro
Georas et al., Blood 1998 : The molecular mechanisms by which IL-4 induces expression of the IL-4 gene are not known, although the IL-4 activated transcription factor signal transducer and activator of transcription 6 ( Stat6 ) is required for this effect