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IL4 — PRG4

Text-mined interactions from Literome

Lubberts et al., Arthritis Rheum 2000 : Reduction of interleukin-17 induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4
Dudler et al., Ann Rheum Dis 2000 (Arthritis) : Effect of interleukin 17 on proteoglycan degradation in murine knee joints
Hashimoto-Uoshima et al., J Periodontal Res 2002 (Gingivitis) : Effects of interleukin-4 on proteoglycan accumulation in human gingival fibroblasts
Henderson et al., Cytokine 1991 (Synovitis) : Inhibition of interleukin-1 induced synovitis and articular cartilage proteoglycan loss in the rabbit knee by recombinant human interleukin-1 receptor antagonist
Kandel et al., J Rheumatol 1990 : Comparison of the effect of interleukin 6 and interleukin 1 on collagenase and proteoglycan production by chondrocytes
Heino et al., Biochem J 1988 : Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein
Bocquet et al., Biochem Biophys Res Commun 1986 : Effect of a interleukin-1 like factor ( mononuclear cell factor ) on proteoglycan synthesis in cultured human articular chondrocytes
Ratcliffe et al., Biochem J 1986 : Characterization of the proteoglycans in the media after 1.5 days and 3 days of culture showed that interleukin 1 promoted the release of proteoglycan of large average size and also the release of link protein and of low-Mr binding region which was unattached to proteoglycan
Wegrowski et al., Biochem J 1995 : Here we report the effects of recombinant human IL-4 on glycosaminoglycan ( GAG ) and proteoglycan synthesis in normal dermal fibroblasts from adult donors
Panthou et al., Biochem Mol Biol Int 1994 : Effects of transforming growth factor-beta 1, interleukin-1 alpha and interleukin-6 on rat Sertoli cell proteoglycan synthesis
Yeh et al., J Rheumatol 1995 : To determine the ability of interleukin-4 (IL-4) to inhibit the degradation of proteoglycan in bovine articular cartilage explants stimulated by human interleukin-1 ( IL-1 alpha ), tumor necrosis factor ( TNF-alpha ), a combination of TNF-alpha and IL-1 alpha, and lipopolysaccharide (LPS) ... IL-4 significantly reduced the cartilage proteoglycan degradation induced by IL-1 alpha, TNF-alpha, TNF-alpha plus IL-1 alpha, or LPS ( 50 % inhibitory concentration, IC50 for IL-4 ranged from about 15 to 50 ng/ml )
Platt et al., Equine Vet J 1994 : An investigation of the proteoglycan metabolism of mature equine articular cartilage and its regulation by interleukin-1