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IL4 — IL7

Text-mined interactions from Literome

De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4 , tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Trindade et al., J Orthop Res 1999 : Interleukin-4 inhibits granulocyte-macrophage colony stimulating factor, interleukin-6 , and tumor necrosis factor-alpha expression by human monocytes in response to polymethylmethacrylate particle challenge in vitro ... Interleukin-4 inhibited the expression of granulocyte-macrophage colony stimulating factor, interleukin-6 , and tumor necrosis factor-alpha at 48 hours in a dose dependent manner
Roy et al., Surgery 2000 : Interleukin-4 regulates macrophage interleukin-12 protein synthesis through a c-fos mediated mechanism
Bonder et al., Cytokine 2002 : While IL-4 can suppress LPS induced interleukin beta ( IL-beta ) and tumour necrosis factor alpha (TNF-alpha) production by monocytes, IL-4 can suppress LPS induced IL-1 beta, but not TNFalpha production by the more differentiated cells
Armitage et al., Cytokine 1992 : In contrast, subdivision of T cells into memory and naive populations using the CD45RO monoclonal antibody ( mAb ) UCHL1, revealed that almost all of the potential to secrete IL-4 and IL-6 in response to IL-7 resided in the CD45RO+ memory population
van Roon et al., Arthritis Res Ther 2003 (Arthritis, Rheumatoid) : CD3/CD28 costimulation and IL-7 were early inducers of IL-4 production, but primarily stimulated IFN-gamma production ... Upon long-term stimulation of naive CD4+ T cells, IFN-gamma production was differentially regulated by IL-7 and IL-4, but IL-4 production was increased by both IL-7 and IL-4
Rollier et al., J Virol 2004 (Hepatitis C, Chronic) : Immunization induced antibodies, peptide-specific gamma interferon ( IFN-gamma ), protein-specific lymphoproliferative responses, IFN-gamma, interleukin-2 (IL-2), and IL-4 T-helper responses in both vaccinees
Raes et al., J Leukoc Biol 2005 (Asthma...) : In addition, we demonstrate that in vitro, interleukin-4 (IL-4) and IL-13 up-regulate mMGL1 and mMGL2 expression and that in vivo, induction of mMGL1 and mMGL2 is dependent on IL-4 receptor signaling
Melk et al., Transplantation 2004 (Growth Disorders...) : During rhGH therapy in children with transplants, interleukin (IL)-2 production increased threefold at 4 weeks, and IL-4 and IL-13 increased by 70 % at 12 weeks
Bouchelouche et al., J Urol 2006 : Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells : synergy with interleukin-1beta and tumor necrosis factor-alpha
Managlia et al., Virology 2006 : Additional neutralization of cytokines present in IL-7 treated cultures and/or those that have NFAT binding sequences within their promotors indicated that IL-10, IL-4 , and most significantly IFNgamma, all contribute to IL-7-induction of HIV productive replication in naive T cells
Stötter et al., J Immunol 1991 : IL-7 induces human lymphokine activated killer cell activity and is regulated by IL-4 ... This may be indirect evidence that IL-7 stimulation leads to induction of IL-4 activity
Yang et al., Zhonghua Jie He He Hu Xi Za Zhi 2006 (Tuberculosis, Pulmonary) : Anti-IL-7 and anti-IL-15 decreased the production of IFN-gamma and TNF-alpha, but increased the production of IL-4 and IL-10
Van Vlasselaer et al., Cell Immunol 1991 : Whereas thymocytes show a minimal response to phytohemagglutinin ( PHA ), IL-2, or IL-4 alone, they proliferate vigorously when cocultured with irradiated cloned NS cells in the presence of PHA or IL-2 or IL-4 , but not with IL-1, IL-3, IL-6, IL-7 , IFN-gamma, or GM-CSF
Morris et al., J Immunol 2009 : IL-4 effects are IL-7- and IL-15 independent, but MHC class I-dependent stimulation appears to be required for the mitogenic effect of IL-4 on naive phenotype CD8 ( + ) T cells
Armitage et al., Adv Exp Med Biol 1991 : Analysis of purified T-cell populations showed that IL-7R were present, and IL-4R could be induced , on both CD4+ and CD8+ populations
Crawley et al., Eur J Immunol 2010 : The role of IL-4 in regulating CD127 expression and IL-7 activity in human thymocytes and mature CD8+ T cells is unknown and was therefore investigated
Xing et al., Chin Med J (Engl) 2011 (Alzheimer Disease) : Ex vivo cultured splenocytes isolated from mice immunized with p ( Aß ( 3-10 ) ) ( 10 ) -CpG exhibited high interleukin-4 response and low interleukin-? ( IFN-? ) response
Uchiyama et al., Journal of cardiothoracic surgery 2012 : Proliferation of splenocytes, interleukin (IL)-2 and interferon ( IFN ) -? production was suppressed in opera exposed mice, and production of IL-4 and IL-10 from opera exposed transplant recipients increased compared to that from splenocytes of untreated recipients
Weiss et al., Eur J Immunol 1989 : Human T cells and interleukin 4 inhibit the release of interleukin 1 induced by lipopolysaccharide in serum-free cultures of autologous monocytes
Conlon et al., Blood 1989 : Thus, IL-7 may cause proliferation of thymocytes directly, not indirectly, through production of IL-2, IL-4 , or IL-6
Hurme et al., Biochem Biophys Res Commun 1988 : Interleukin-4 inhibits interleukin-1 synthesis by a posttranscriptional mechanism ... Interleukin-4 had a clear dose dependent suppressive effect on the interleukin-1 synthesis
Tortolani et al., J Immunol 1995 (Leukemia) : In addition, IL-4 and IL-7 induced the rapid tyrosine phosphorylation of JAK3 and JAK1, and IL-4 activated both JAK3 and JAK1 phosphotransferase activity
Dokter et al., Exp Hematol 1994 : We studied the effect of the stroma derived cytokine interleukin-7 (IL-7) on the expression of IL-4 in human T cells at mRNA and protein level ... In contrast, IL-7 augmented the con A-induced secretion of IL-4 protein significantly ... In addition, it was noticed that anti-IL-1 beta and anti-tumor necrosis factor-alpha ( anti-TNF-alpha ) did not abolish the effect of IL-7 on the con A-induced IL-4 secretion, indicating that the IL-7 effect is not mediated by the release of these cytokines
Xu et al., Kidney Int 1995 : Our investigation demonstrated that : ( a ) intragraft expression of IL-10 mRNA and IL-2 mRNA are significant correlates of acute rejection ; ( b ) IL-4 , IL-7, IFN-gamma and TGF-beta 1 mRNA expression do not correlate with acute rejection ; and ( c ) IL-10 does not prevent in vivo expression of IFN-gamma, IL-2, IL-7 , or TGF-beta 1
Borger et al., J Immunol 1996 : We investigated the role of IL-7 on the expression of IFN-gamma and IL-4 in human T lymphocytes ... Used at an optimal concentration, IL-7 ( 5 ng/ml ) increased the accumulation of IFN-gamma ( eightfold ) and IL-4 ( 2.5-fold ) mRNAs, which could not be blocked by anti-IL-12 treatment ... mRNA stability studies revealed that IL-7 stabilizes both IFN-gamma and IL-4 mRNA transcripts : 40 and 60 min in anti-CD3/anti-CD28 stimulated T cells vs 120 and 90 min in T cells costimulated with anti-CD3/anti-CD28 plus IL-7 ... However, the promotive effect of IL-7 on IFN-gamma and IL-4 gene expression could be blocked by genistein and cyclosporin A
Benveniste et al., Proc Natl Acad Sci U S A 1996 (Acute Disease...) : Comparative interleukin ( IL-2 ) /interferon IFN-gamma and IL-4/IL-10 responses during acute infection of macaques inoculated with attenuated nef truncated or pathogenic SICmac251 virus
Salvucci et al., Eur J Immunol 1996 : Differential regulation of interleukin-12- and interleukin-15 induced natural killer cell activation by interleukin-4
Vicari et al., Int Immunol 1996 : Finally, IL-7 but not IL-2 or IL-4 was able to maintain and increase IL-4 production by NK1.1+ thymocytes from normal mice
Webb et al., Eur J Immunol 1997 : IL-7 induced IL-4 production is not inhibited by neutralizing antibodies to IL-4 on its receptor ... We propose that in conjunction with CD28 co-stimulation, IL-7 induces the initial expression of IL-4 production and that IL-4 acts subsequently to expand Th2 cytokine producing cells at the appropriate anatomical site
Gollob et al., Eur J Immunol 1997 : Interferon-gamma and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression
Nishizawa et al., Int Immunol 1997 : In contrast to IL-2, IL-7 does not induce LGL cells or NK activity from DN alpha beta TCR+NK1.1- cells but induces the ability to produce high levels of IL-4 upon TCR cross linking
Jiang et al., Clin Immunol Immunopathol 1998 : Regulation of human lymphocyte IL-4 secretion by intestinal epithelial cell derived interleukin-7 and transforming growth factor-beta