Escoubet-Lozach et al., Eur Cytokine Netw 2001
:
In peritoneal macrophages from control rats ( cPM ), IL-4 had no effect on cPLA2 and 5-LO expression, but increased FLAP expression without affecting basal and A23187- or PMA challenged arachidonic acid ( AA ) metabolism ... Thus, IL-4 acts differently on cPLA2, 5-LO and FLAP expression and AA metabolism in peritoneal macrophages depending on their resident or sensitization induced differentiated status
Escoubet-Lozach et al., Clin Exp Allergy 2001
:
IL-4 induced FLAP expression in cPM but had no effect on cPLA2 and 5-LO expression