Gene interactions and pathways from curated databases and text-mining

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IL10 — TNFSF4

Text-mined interactions from Literome

Ito et al., J Exp Med 2005 : We further revealed the following three novel functional properties of OX40L : ( a) OX40L selectively promoted TNF-alpha, but inhibited IL-10 production in developing Th2 cells ; ( b ) OX40L lost the ability to polarize Th2 cells in the presence of IL-12 ; and ( c) OX40L exacerbated IL-12 induced Th1 cell inflammation by promoting TNF-alpha, while inhibiting IL-10
Ito et al., Proc Natl Acad Sci U S A 2006 : In addition, OX40L strongly inhibited IL-10 production and suppressive function of differentiated IL-10 producing Tr1 cells
Gopisetty et al., J Immunol 2013 (Disease Models, Animal...) : Adoptive transfer of only OX40L ( + ) Jagged1 ( + ) BMDCs led to Treg expansion, increased production of IL-4 and IL-10 , and suppression of EAT in the recipient mice