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IL10 — TNFSF4
Text-mined interactions from Literome
Ito et al., J Exp Med 2005
:
We further revealed the following three novel functional properties of OX40L : ( a)
OX40L selectively promoted TNF-alpha, but
inhibited IL-10 production in developing Th2 cells ; ( b ) OX40L lost the ability to polarize Th2 cells in the presence of IL-12 ; and ( c) OX40L exacerbated IL-12 induced Th1 cell inflammation by promoting TNF-alpha, while inhibiting IL-10
Ito et al., Proc Natl Acad Sci U S A 2006
:
In addition,
OX40L strongly
inhibited IL-10 production and suppressive function of differentiated IL-10 producing Tr1 cells
Gopisetty et al., J Immunol 2013
(Disease Models, Animal...) :
Adoptive transfer of only
OX40L ( + ) Jagged1 ( + ) BMDCs
led to Treg expansion, increased production of IL-4 and
IL-10 , and suppression of EAT in the recipient mice