◀ Back to MAPK8

GNRH1 — MAPK8

Text-mined interactions from Literome

Han et al., Endocrinology 1999 : Treatment of PKC depleted cells with Buserelin activated MAPK, suggesting involvement of PKC independent signal transduction pathways in MAPK activation in response to GnRH
Maurer et al., Recent Prog Horm Res 1999 : We found that GnRH can indeed activate MAPK and that MAPK activation is sufficient and necessary for transcriptional activation of the alpha-subunit gene
Kang et al., Endocrinology 2001 : In addition, pretreatment with a PKC activator, phorbol-12-myristate 13-acetate, potentiated GnRH induced MAPK activation
Kang et al., Mol Cell Endocrinol 2000 : Cell cultures were treated with various concentrations of a GnRH agonist, ( D-Ala ( 6 ) ) -GnRH, for 5 min. ( D-Ala ( 6 ) ) -GnRH stimulated a rapid activation of P-MAPK in human granulosa-luteal cells ( hGLCs ) and immortalized extravillous trophoblast ( IEVT ) cells
Gur et al., Comp Biochem Physiol B Biochem Mol Biol 2001 (MAP Kinase Signaling System) : The role of mitogen activated protein kinase ( MAPK, also known as extracellular signal regulated kinase ; ERK ) stimulation in gonadotropin releasing hormone (GnRH) signaling was investigated in cultured pituitary cells of tilapia hybrids ( Oreochromis niloticus x O. aureus )
Zhang et al., J Biol Chem 2001 (Calcium Signaling) : In pituitary gonadotropes, gonadotropin releasing hormone (GnRH) activates all three major mitogen activated protein kinase ( MAPK ) cascades ... In pituitary gonadotropes, gonadotropin releasing hormone (GnRH) activates all three major mitogen activated protein kinase ( MAPK ) cascades
Liu et al., Mol Endocrinol 2002 : In this paper, we demonstrate that GnRH activates ERK, c-Jun N-terminal kinase, and p38MAPK in the LbetaT2 gonadotrope cell line
Shah et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Dependence of gonadotropin releasing hormone induced neuronal MAPK signaling on epidermal growth factor receptor transactivation
Liu et al., Endocrinology 2003 (Calcium Signaling) : Activation of individual signaling pathways was able to partially mimic the desensitizing effect of GnRH on ERK, p38 MAPK , c-fos, and LHbeta but not on Gq/11
Roelle et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Activation of c-Jun N-terminal kinase and p38 MAPK by GnRH was unaffected by EGFR or gelatinase inhibition that, however, suppressed GnRH induction of c-Jun and c-Fos
Xie et al., Mol Endocrinol 2005 (MAP Kinase Signaling System) : These studies support the conclusion that the dual CREs of the human alpha-subunit promoter are the target of GnRH induced MAPK regulation through ATF3
Zhang et al., J Mol Endocrinol 2006 : In the present study, we investigated the function of GnRH induced MAPK phosphatases ( MKPs ) using an in vivo mouse model as well as the alphaT3-1 cell line
Dobkin-Bekman et al., Mol Cell Endocrinol 2006 : Activation of mitogen activated protein kinase ( MAPK ) by GnRH is cell-context dependent
Zhang et al., Mol Endocrinol 2006 : Therefore, we demonstrated that activin enhanced GnRH induction of p38MAPK activity, caused GnRH dependent phosphorylation of p53, and reduced the ability of GnRH to cause G1 arrest
Eicke et al., Int J Oncol 2006 (Endometrial Neoplasms...) : We showed that [ D-Lys6 ] GnRH-II reduces EGF induced auto-tyrosine-phosphorylation of EGF-receptors via activation of a PTP and that EGF induced activation of mitogen activated protein kinase was blocked in cells treated with [ D-Lys6 ] GnRH-II
Coss et al., Mol Endocrinol 2007 : We find that the cross-talk between the GnRH and activin signaling pathways occurs at the level of p38 MAPK, because the synergy is dependent on p38 MAPK activity, which is activated by GnRH , and activin cotreatment augments p38 activation by GnRH
Xie et al., Endocrinology 2008 (MAP Kinase Signaling System) : 3 ', 5'-cyclic adenosine 5'-monophosphate response element dependent transcriptional regulation of the secretogranin II gene promoter depends on gonadotropin releasing hormone induced mitogen activated protein kinase activation and the transactivator activating transcription factor 3
Nicol et al., J Endocrinol 2008 : However, the GnRH induced activation of p38 MAPK was decreased by BMP-4
White et al., Mol Endocrinol 2008 (MAP Kinase Signaling System) : We show that in Galpha ( q/11 ) -negative cells stably expressing the GnRH receptor, GnRH did not induce activation of ERK, jun-N-terminal kinase, or P38 MAPK
Dhillon et al., Regul Pept 2009 : Pharmacological inhibitors of the MAPK and PKA signal transduction pathways attenuated the NPY mediated increase in GnRH transcription
Burger et al., Biol Reprod 2009 : Inhibitors of mitogen activated protein kinase 8/9 ( MAPK8/9 [ also known as JNK ] ; SP600125 ) and MAP Kinase Kinase 1 ( MAP2K1 [ also known as MEK1 ] ; PD98059 ) either blunted or totally suppressed the GNRH induction of Lhb PT and Egr1 PT/mRNA, whereas the MAPK14 ( also known as p38 ) inhibitor SB203580 did not
Lim et al., PloS one 2009 (MAP Kinase Signaling System) : A fourth MAPK , ERK5, was shown also to be activated by GnRH
Kotitschke et al., Mol Endocrinol 2009 : Using kinase inhibitors, we established a direct link between GnRH induced protein kinase C and MAPK activation, leading to unliganded GR phosphorylation at Ser-234 and transactivation of the glucocorticoid response element
Naidich et al., Endocrinology 2010 : PGF ( 2alpha ), PGI ( 2 ), or PGE ( 2 ) had no effect on GnRH stimulated ERK, c-Jun N-terminal kinase, and p38MAPK activation or on GnRH- and high K ( + ) -stimulated intracellular Ca ( 2+ ) elevation in LbetaT2 and gonadotropes in primary culture
Takeda et al., Mol Cell Endocrinol 2012 (MAP Kinase Signaling System) : Since GnRH stimulated MAPK phosphorylation in LßT2 cells, a functional link between MAPK and FSHß transcription was examined ... Co-treatment with BMP-7, but not with BMP-6, suppressed GnRH induced MAPK phosphorylation in LßT2 cells
Roberson et al., Mol Cell Biol 1995 : A reporter gene assay using the MAPK-responsive, carboxy-terminal domain of the Elk1 transcription factor was also consistent with GnRH induced activation of MAPK
Sundaresan et al., Endocrinology 1996 : Stimulation of mitogen activated protein kinase by gonadotropin releasing hormone : evidence for the involvement of protein kinase C ... In this study, we investigated whether GnRH stimulates mitogen activated protein kinase ( MAPKs ), and whether this pathway plays a role in the transcriptional activation of the gonadotropin alpha-gene ... Stimulation of MAPK activity was detected within 5 min of GnRH treatment and persisted for 60 min. MAPK activation by GnRH was also seen in primary cultures of rat pituitary cells ... Pretreatment with TPA, however, decreased both GnRH- and TPA induced MAPK activation, suggesting that PKC is involved in GnRH mediated activation of MAPK ... These experiments indicate that GnRH stimulates MAPK activity, probably through a pathway involving PKC
Haisenleder et al., Endocrinology 1998 : Initial studies revealed that pulsatile GnRH stimulated a dose dependent rise in MAPK activity ( 30 ng, 2-fold increase ; 100 ng, 4-fold ; 300 ng, 8-fold ) 4 min after the pulse ... In contrast, continuous GnRH only increased MAPK activity ( 2- to 3-fold ; P < 0.05 vs. controls ) for 2 h, with MAPK activity returning to baseline at later time points ... Preliminary studies demonstrated that the MAPK inhibitor, PD-098059 ( 50 microM ), completely blocked GnRH induced increases in MAPK activity in adult male pituitary cells