◀ Back to PLK1

PLK1 — PPP2CA

Pathways - manually collected, often from reviews:

• NCI Pathway Database PLK1 signaling events: PP2A-alpha B56 complex (PPP2R1A-PPP2CA) → PLK1 (PLK1) (translocation, inhibits) Tang et al., Dev Cell 2006*
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Lu et al., Proc Natl Acad Sci U S A 2009 (Glioblastoma...) : We demonstrate that a small molecule inhibitor, LB-1.2, of protein phosphatase 2A (PP2A) activates Plk-1 and Akt-1 and decreases p53 abundance in tumor cells
Suijkerbuijk et al., Dev Cell 2012 : As a result, removal of BUBR1 from mitotic cells or inhibition of PLK1 reduces PP2A-B56a kinetochore binding and elevates phosphorylation of Aurora B substrates on the outer kinetochore