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ACHE — CTNND1

Text-mined interactions from Literome

Moretto et al., Toxicol Lett 1998 (Peripheral Nervous System Diseases) : Inhibition of AChE ( phosphorylation ) by most OPs is irreversible whereas CAs reversibly inhibit AChE ( spontaneous reactivation with a t(1/2) of minutes ) ; dimethylphosphorylated AChE partially and slowly ( t(1/2) = 1-2 h ) reactivates
Arce et al., J Med Chem 2009 (Alzheimer Disease) : With an L-glutamic moiety as a suitable biocompatible linker, three pharmacophoric groups were joined : ( 1 ) an N-benzylpiperidine fragment selected to inhibit acetylcholinesterase by interacting with the catalytic active site (CAS) , ( 2 ) an N-protecting group of the amino acid, capable of interacting with the acetylcholinesterase (AChE)-peripheral anionic site ( PAS ) and protecting neurons against oxidative stress, and ( 3 ) a lipophilic alkyl ester that would facilitate penetration into the central nervous system by crossing the blood-brain barrier