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Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
PTPN11
→
F2
(decreases, F2 Activity, PTPN11 Activity)
Dudek et al., J Appl Physiol 2001* Evidence: whereas tyrosine kinase inhibition attenuated these effects (62). Recent work suggests that, in addition to increasing contractile forces, thrombin also alters EC permeability through dissociation of the tyrosine phosphatase, SHP2, from VE-cadherin complexes to produce increased tyrosine phosphorylation of catenins and subsequent destabilization of adherens junction linkage to the cytoskeleton (145).