UCSC Genome Browser Gene Interaction Graph

We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Gene interactions and pathways from curated databases and text-mining

◀ Back to HSP90AA1

HSP90AA1 — TFRC

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Intact Interaction: Complex of 306 proteins (association, pull down) Komarova et al., Mol Cell Proteomics 2011
IRef Intact Interaction: Complex of 64 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
IRef Intact Interaction: Complex of 203 proteins (association, cross-linking study) Byron et al., Proteomics 2012
IRef Intact Interaction: Complex of 156 proteins (association, anti tag coimmunoprecipitation) Lau et al., Cell 2012

Text-mined interactions from Literome

Zhai et al., J Pharm Biomed Anal 2010 : Determination of SNX-2112 , a selective Hsp90 inhibitor , in plasma samples by high-performance liquid chromatography and its application to pharmacokinetics in rats
Bachleitner-Hofmann et al., Clin Cancer Res 2011 : The aim of our study was to assess the efficacy of SNX-2112 , a synthetic HSP-90 inhibitor , in 3 different MET amplified tumor cell lines ( GTL-16, MKN-45, and EBC-1 ) as well as PR-GTL-16 cells, a GTL-16 subline selected for resistance to the highly selective MET kinase inhibitor PHA-665752
Zhai et al., Biomed Pharmacother 2011 : Preclinical pharmacokinetic analysis of SNX-2112 , a novel Hsp90 inhibitor , in rats