UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PSEN1

CASP3 — PSEN1

Pathways - manually collected, often from reviews:

BioCarta hiv-1 nef: negative effector of fas and tnf: Caspase 3/6 inactivated structural proteins (SPTAN1/LMNB1/LMNA/PSEN1/GSN/LMNB2/PSEN2) → Caspase 3 (active) (CASP3) (degradation, collaborate)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Bind Interaction: CASP3 — PSEN1 van de Craen et al., FEBS Lett 1999
IRef Bind_translation Interaction: CASP3 — PSEN1 (experimental interaction detection) van de Craen et al., FEBS Lett 1999
IRef Hprd Interaction: PSEN1 — CASP3 (in vitro) van de Craen et al., FEBS Lett 1999
IRef Hprd Interaction: PSEN1 — CASP3 (in vivo) van de Craen et al., FEBS Lett 1999
IRef Ophid Interaction: PSEN1 — CASP3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kovacs et al., J Neurochem 1999 (Alzheimer Disease...) : Here we explore the effects of FAD mutant forms of PS1 on caspase activation during apoptosis
Xie et al., Brain Res 2001 (Alzheimer Disease) : Antisense par-4 treatment largely suppressed the adverse effect of the mutant PS-1 on mitochondrial dysfunction and caspase activation
Chae et al., J Neurosci Res 2010 : These results suggest that caspase-2 and/or -8 is involved in presenilin/gamma-secretase activation and Abeta production in apoptosis