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ESR2 — NCOA3

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated nuclear estrogen receptor beta network: AIB1 (NCOA3) → E2/ERB (dimer) complex (ESR2) (modification, collaborate)
  Katzenellenbogen et al., Ann N Y Acad Sci 2001
  Evidence: physical interaction
• NCI Pathway Database Validated nuclear estrogen receptor beta network: AIB1 (NCOA3) → E2/ERB (dimer)/AIB1 complex (ESR2-NCOA3) (modification, collaborate)
  Katzenellenbogen et al., Ann N Y Acad Sci 2001
  Evidence: physical interaction
• NCI Pathway Database Validated nuclear estrogen receptor beta network: E2/ERB (dimer) complex (ESR2) → E2/ERB (dimer)/AIB1 complex (ESR2-NCOA3) (modification, collaborate)
  Katzenellenbogen et al., Ann N Y Acad Sci 2001
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: NCOA3 — ESR2 (physical association, affinity chromatography technology) Mc Ilroy et al., Endocr Relat Cancer 2006*
• IRef Biogrid Interaction: NCOA3 — ESR2 (direct interaction, fluorescent resonance energy transfer) Bai et al., Mol Endocrinol 2003*
• IRef Biogrid Interaction: NCOA3 — ESR2 (direct interaction, unspecified method) Bramlett et al., Mol Endocrinol 2001*
• IRef Biogrid Interaction: NCOA3 — ESR2 (direct interaction, two hybrid) Suen et al., J Biol Chem 1998*
• IRef Biogrid Interaction: NCOA3 — ESR2 (physical association, affinity chromatography technology) Nassa et al., Proteomics 2011
• IRef Biogrid Interaction: NCOA3 — ESR2 (direct interaction, pull down) Wong et al., Biochemistry 2001*
• IRef Biogrid Interaction: NCOA3 — ESR2 (direct interaction, pull down) Leo et al., J Biol Chem 2000*
• IRef Biogrid Interaction: NCOA3 — ESR2 (direct interaction, fluorescent resonance energy transfer) Iannone et al., Cytometry 2001
• IRef Hprd Interaction: ESR2 — NCOA3 (in vitro) Leo et al., J Biol Chem 2000*, Wong et al., Biochemistry 2001*
• IRef Hprd Interaction: ESR2 — NCOA3 (in vivo) Leo et al., J Biol Chem 2000*, Wong et al., Biochemistry 2001*
• IRef Intact Interaction: Complex of 143 proteins (association, cosedimentation through density gradient) Nassa et al., Proteomics 2011
• IRef Intact Interaction: Complex of 43 proteins (association, pull down) Nassa et al., Proteomics 2011
• IRef Ophid Interaction: NCOA3 — ESR2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Planas-Silva et al., Cancer Res 2001 (Breast Neoplasms) : We show here that AIB1 and other steroid receptor coactivators can enhance the functional interaction of the estrogen receptor with the cyclin D1 promoter
Hossain et al., Mol Cell Biol 2006 (Breast Neoplasms) : We also found that downregulation of AIB1 by Mir-17-5p resulted in decreased estrogen receptor mediated, as well as estrogen receptor independent, gene expression and decreased proliferation of breast cancer cells
Li et al., Mol Cell 2008 (Breast Neoplasms) : PDXP and PP2A dephosphorylate SRC-3 and inhibit its ligand dependent association with estrogen receptor