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MAPK15 — SRC

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: SRC — MAPK15 (in vivo) Abe et al., J Biol Chem 2002*
• IRef Hprd Interaction: SRC — MAPK15 (in vitro) Abe et al., J Biol Chem 2002*

Text-mined interactions from Literome

Daly et al., Oncogene 1999 : All three ligands induced short-term activation of p38 MAPK in a c-Src dependent manner
Munshi et al., J Immunol 2000 (MAP Kinase Signaling System...) : Further studies using mutants of c-Src kinase revealed that Src mediates mitogen activated protein kinase activation induced by VEGF
Nebigil et al., Proc Natl Acad Sci U S A 2000 (MAP Kinase Signaling System) : Inhibition of c-Src activity by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ( PP1 ) or depletion of c-Src is sufficient to abolish the 5-HT induced ( i ) PDGFR tyrosine kinase phosphorylation and MAPK activation, ( ii ) cyclin D1 and cyclin E expression levels, and ( iii ) thymidine incorporation
Graness et al., Biochem J 2000 : Although Src does not participate in bradykinin induced stimulation of PTP activity, inhibition of Src by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo ( 3,4-d ) pyrimidine leads to an increase in MAPK activation by bradykinin
Schmid et al., J Neurosci 2000 (MAP Kinase Signaling System...) : The nonreceptor tyrosine kinase pp60(c-src) was required for L1-triggered MAPK phosphorylation, as shown in src-minus cerebellar neurons and by expression of the kinase-inactive mutant Src ( K295M ) in B35 neuroblastoma cells
Bondzi et al., Cell Growth Differ 2000 (Carcinoma, Small Cell...) : Src family kinase activity is required for Kit mediated mitogen activated protein ( MAP ) kinase activation, however loss of functional retinoblastoma protein makes MAP kinase activation unnecessary for growth of small cell lung cancer cells
Robinson et al., Eur J Pharmacol 2001 : The Src tyrosine kinase inhibitor PP2 ( 4-amino-5- ( 4-chlorophenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ) and the epidermal growth factor receptor tyrosine kinase inhibitor AG1478 ( 4- ( 3-chloroanilino ) -6,7-dimethoxyquinazoline ) also had no effect on adenosine A(1) receptor stimulation of p42/p44 MAPK
Simeonova et al., Mol Cell Biochem 2002 : One of this pathways might include c-Src dependent EGFR and MAPK activation
Xiang et al., Zhejiang Da Xue Xue Bao Yi Xue Ban 2003 : To further clarify the mechanism of Ang II-induced intracellular signal transduction in vascular smooth muscle cells ( VSMCs ) proliferation by observing the effect of c-Src on Ang II-mediated MAPK activation and c-fos protein expressions in rat VSMCs
Khadaroo et al., Surgery 2003 : Oxidant stress generated during global ischemia/reperfusion activates p38 MAPK in an Src dependent manner
Recchia et al., Bone 2004 (Adenocarcinoma, Clear Cell...) : c-Src inhibition stabilized p38 mitogen activated protein kinase ( MAPK ), whereas the c-Jun N-terminal kinase (JNK) pathway did not appear to be modulated by our compounds
Tsuruda et al., FEBS Lett 2004 (MAP Kinase Signaling System...) : Constitutively active Src facilitates NGF induced phosphorylation of TrkA and causes enhancement of the MAPK signaling in SK-N-MC cells
Salinthone et al., Am J Physiol Gastrointest Liver Physiol 2004 (Inflammation) : Expression of IL-1beta, IL-6, IL-8, and COX-2 mRNA was reduced by 30 microM PP1, an Src family tyrosine kinase inhibitor, and by 25 microM SB-203580, a p38 MAPK inhibitor
Waters et al., Cell Signal 2005 : Indeed, the PDGF dependent activation of p42/p44 MAPK was reduced by over-expression of the C-terminal domain of GRK2 ( sequesters Gbetagamma subunits ), the clathrin binding domain of beta-arrestin and by inhibitors of c-Src and clathrin mediated endocytosis
Amos et al., J Biol Chem 2005 (Glioblastoma) : The effects of PMA on MAPK phosphorylation and glioblastoma cell proliferation were reduced by BIM, rottlerin, the MEK inhibitor U0126, and PKCdelta and c-Src siRNAs
Callera et al., Hypertension 2005 : We tested the hypothesis that aldosterone induces activation of vascular mitogen activated protein ( MAP ) kinases and NADPH oxidase via c-Src dependent mechanisms in vascular smooth muscle cells ( VSMCs )
Zhou et al., Toxicological sciences : an official journal of the Society of Toxicology 2005 : MAPK phosphorylation by two other translational inhibitors, anisomycin and emetine, were similarly Src dependent
Zubkov et al., J Cardiovasc Pharmacol 2004 : The following results were observed : ( 1 ) endothelin-1 produced phosphorylation of MAPK and RhoA and contraction by activation of endothelin-A but not endothelin-B receptors ; ( 2 ) MAPK inhibitors, PD 98059 and U0126, PTK inhibitor, genistein, Src kinase inhibitor , damnacanthal, and Janus tyrosine kinase ( JAK2 ) inhibitor, AG-490, abolished endothelin-1 induced contraction and MAPK immunoreactivity ; ( 3 ) PTK inhibitor, staurosporine, and phosphatidylinositol 3-kinase (PI- 3K) inhibitor wortmannin abolished endothelin-1 induced contraction but not MAPK immunoreactivity ; ( 4 ) Rho-kinase inhibitor, Y-27632, reduced endothelin-1 induced contraction ; ( 5 ) PI-3K inhibitor, wortmannin, but not PKC and PTK inhibitors, reduced endothelin-1 induced RhoA activation ; ( 6 ) endothelin-1 increased the level of myosin light chain ( MLC ) phosphorylation, and Rho-kinase inhibitor, Y-27632, reduced the effect of endothelin- 1 on MLC phosphorylation
Wei et al., J Biol Chem 2005 (MAP Kinase Signaling System) : However, deletion of this region in the context of human RON enhanced receptor phosphorylation, activation of mitogen activated protein kinase , and association of c-Src at levels comparable with those observed with mouse RON
Gelain et al., Cell Signal 2006 : In this work, we report that, in Sertoli cells, retinol ( 7 microM ) induces the Src dependent activation of ERK1/2 MAPK and the ERK1/2 mediated phosphorylation of the transcription factor CREB
Carini et al., J Hepatol 2006 (Anoxia...) : ATPgammaS activated Src and promoted a Src dependent stimulation of both ERK1/2 and p38MAPK
Pardo et al., Biogerontology 2007 : Extracellular and intracellular Ca ( 2+ ) chelation or c-Src pharmacological inhibition suppressed hormone activation of p38 MAPK in both, young and aged rats, demonstrating that Ca ( 2+ ) and the non-receptor tyrosine kinase c-Src are required for full activation of p38 MAPK in cells stimulated with 1alpha,25 ( OH ) ( 2 ) D ( 3 )
Galliher et al., Breast Cancer Res 2006 (Breast Neoplasms...) : Inhibiting Src activity in MECs prevented the ability of beta3 integrin to induce TbetaR-II tyrosine phosphorylation, MAPK activation, and EMT stimulated by TGF-beta
Hodges et al., Invest Ophthalmol Vis Sci 2006 : Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK
Fleming et al., Endocrinology 2006 : Unexpectedly, inhibition of Src increased basal MAPK activation
Cheng et al., Endocrinology 2007 : In addition, we demonstrate that Src kinase is activated by T and that Src kinase activity is required for stimulation of the ERK MAPK and CREB
Galliher et al., Cancer Res 2007 (MAP Kinase Signaling System...) : Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion
Yaghini et al., J Biol Chem 2007 : These data suggest that Syk expressed in VSMC is activated by Ang II through p38 MAPK activated c-Src subsequent to cytosolic phospholipase A ( 2 ) and generation of AA metabolites via LO, and it mediates Ang II-induced protein synthesis independent of epidermal growth factor receptor transactivation ( Ang II -- > cPLA(2) -- > AA metabolites of LO -- > p38 MAPK -- > c-Src -- > Syk -- > protein synthesis )
Lim et al., Arch Biochem Biophys 2007 (MAP Kinase Signaling System) : Inhibition of c-Src suppressed Raf/MEK/ERK pathway but activated p38 MAPK ... Inhibition of p38 MAPK did not affect c-Src activity in PM
Slomiany et al., Inflammopharmacology 2008 : Our findings demonstrate that leptin protection of salivary gland acinar cells against ethanol cytotoxicity involves Src kinase mediated parallel activation of MAPK/ERK and Akt that result in up-regulation of the respective prostaglandin and nitric oxide synthase pathways
Eblin et al., Toxicology 2008 : To determine importance of ROS in the MAPK cascade and its downstream induction of p-Src and COX-2, specific ROS antioxidants ( both enzymatic and non-enzymatic ) were used concomitantly with arsenicals
Chaturvedi et al., Mol Cell Biochem 2008 : Src inhibition increased mitogen activated protein kinase phosphatase-1 protein and decreased phosphorylation of SF-1, which correlated with increased CYP17 promoter activity and mRNA levels
Kim et al., Mol Cancer Res 2008 (MAP Kinase Signaling System...) : Inhibition of c-Src by pretreatment with Src family kinase inhibitor PP2 or small interfering RNA targeting of c-Src attenuated radiation induced p38 MAPK and Rac1 activation and enhanced Bax and Bak activation and cell death
Kim et al., Mol Cancer Res 2008 (MAP Kinase Signaling System...) : Inhibition of c-Src attenuated Rac1 and p38 MAPK activations and Ser ( 473 ) phosphorylation of Akt
Schweppe et al., J Clin Endocrinol Metab 2009 (Carcinoma...) : Phospho-ERK1/2 was not affected by AZD0530, indicating that Src signaling does not require MAPK
Chai et al., IUBMB Life 2009 : The current study investigated a possible role for p38 MAPK in the regulation of ( SRC ) -3 phosphorylation/degradation and in retinoic acid receptor (RAR)alpha signaling in mouse fetal cortical neurons treated with all-trans retinoic acid ( ATRA )
Watanabe et al., Mol Cancer Res 2009 (Sarcoma, Synovial) : Adaptor protein Crk induces Src dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation
Hsieh et al., Neurotox Res 2010 : Taken together, these results suggested that in RBA-1 cells, activation of NF-kappaB by a c-Src dependent PI3K/Akt-p42/p44 MAPK activation mediated through transactivation of PDGFR is essential for MMP-9 gene upregulation induced by LTA
Zhang et al., Biochem Pharmacol 2010 (Breast Neoplasms...) : By contrast, S3I-201.1066 has no effect on Src activation or the EGFR mediated activation of the Erk1/2 ( MAPK ) pathway
Ronda et al., J Steroid Biochem Mol Biol 2010 : Role of estrogen receptors, PKC and Src in ERK2 and p38 MAPK signaling triggered by 17ß-estradiol in skeletal muscle cells
Vallabhaneni et al., Breast Cancer Res Treat 2011 (Breast Neoplasms) : Depletion of Src using shRNA substantially reduced E2 mediated activation of Src and MAPK activation in resistant model cells
Lei et al., Am J Physiol Lung Cell Mol Physiol 2011 : In summary, in adult rat AECs T3-stimulated Src kinase activity can activate both PI3K/Akt and MAPK/ERK1/2 , and activation of Akt is necessary for T3-induced Na-K-ATPase activity
Bhattacharjee et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Our data show that Src kinase activity regulates IL-13 induced p38 MAPK tyrosine phosphorylation via the upstream kinases MKK3 or MKK6
Duru et al., J Surg Res 2012 : Src inhibition with PP2 reduced p38 ( MAPK ) and JNK activation but did not alter ERK1/2 activation
Liu et al., Mol Cell Biol 1998 (Cell Transformation, Neoplastic) : Expression of WT-PTP1B reduces formation of p130Cas-Crk complexes and inhibits mitogen activated protein kinase activation by Src and Crk