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GNRH2 — MAPK15
Text-mined interactions from Literome
Zhang et al., J Biol Chem 2001
(Calcium Signaling) :
In pituitary gonadotropes,
gonadotropin releasing hormone (GnRH)
activates all three major mitogen activated protein kinase (
MAPK ) cascades
Shah et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Dependence of
gonadotropin releasing hormone induced neuronal
MAPK signaling on epidermal growth factor receptor transactivation
Kim et al., J Clin Endocrinol Metab 2004
(Adenocarcinoma...) :
In this study, the
effect of
GnRH-II on the activation of p38
MAPK was investigated, and its possible role in the regulation of cell proliferation and apoptosis was further examined in the human ovarian cancer cell line, OVCAR-3 ... The
activation of p38
MAPK by
GnRH-II was reversed in the presence of a specific inhibitor of p38 MAPK, SB203580 ( 1 microM )
Kim et al., J Clin Endocrinol Metab 2005
(Adenocarcinoma...) :
We have previously demonstrated that
GnRH-II activates p38
MAPK
Eicke et al., Int J Oncol 2006
(Endometrial Neoplasms...) :
We showed that [ D-Lys6 ]
GnRH-II reduces EGF induced auto-tyrosine-phosphorylation of EGF-receptors via activation of a PTP and that EGF induced activation of
mitogen activated protein kinase was
blocked in cells treated with [ D-Lys6 ] GnRH-II
Xie et al., Endocrinology 2008
(MAP Kinase Signaling System) :
3 ', 5'-cyclic adenosine 5'-monophosphate response element dependent transcriptional regulation of the secretogranin II gene promoter depends on
gonadotropin releasing hormone induced mitogen activated protein kinase activation and the transactivator activating transcription factor 3
Wu et al., Cancer Res 2009
(Endometrial Neoplasms) :
GnRH-II activated extracellular signal regulated kinase ( ERK)-1/2 and p38
mitogen activated protein kinase ( MAPK ) in a time dependent manner, and the activation was abolished by GnRH-I receptor siRNA and MAPK inhibitors
Sundaresan et al., Endocrinology 1996
:
Stimulation of
mitogen activated protein kinase by
gonadotropin releasing hormone : evidence for the involvement of protein kinase C