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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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HSPG2 — PLCB1

Text-mined interactions from Literome

Xu et al., J Biol Chem 2001 : Overexpression of either a PLC beta1 mutant in which the PKC phosphorylation site Ser ( 887 ) was replaced by alanine, or a dominant negative PKC alpha, resulted in a sustained activation of nuclear PLC following IGF-I stimulation
Kelley et al., Mol Cell Endocrinol 2001 : Overexpression of PLC beta 1 or PLC delta 1 significantly increased PLC activity in isolated cell fractions, consistent with overexpression of active PLC isoforms in these clones
Zhou et al., Am J Physiol Cell Physiol 2004 : PLC-beta activity was partially inhibited by pertussis toxin ( PTX ), Gbeta or Galpha ( q ) antibody, PLC-beta1 or PLC-beta3 antibody, and by expression of Galpha ( q ) or Galpha ( i ) minigene, and was abolished by a combination of antibodies or minigenes
Murthy et al., Mol Pharmacol 1995 : In contrast, cholecystokinin stimulated PLC activity was selectively blocked by PLC-beta 1- and G alpha q/11-specific antibodies
Piiper et al., Gastroenterology 1997 : Anti-PLC-beta1 , -beta3, and Gq/11alpha antibodies inhibited bombesin induced PLC activity by 50 %, 35 %, and 65 %, respectively