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GHRH — MAPK4

Text-mined interactions from Literome

Pombo et al., Endocrinology 2000 : We studied in this work whether GHRH can also stimulate mitogen activated protein ( MAP ) kinase
Zeitler et al., Endocrine 2000 (MAP Kinase Signaling System) : MAPK activation by GHRH was dose dependent from 1 to 100 nM, was evident at 2.5 min, peaked at 5 min, and returned to baseline by 20 min. Pretreatment of GH4 cells with somatostatin analog BIM23014 or the MEK1 inhibitor PD98095 prevented the activation of MAPK ... Furthermore, activation of MAPK may mediate , at least in part, the effects of GHRH on somatotroph cell line proliferation
Pombo et al., Horm Res 2001 : More recently, it was found that GHRH can also activate mitogen activated protein ( MAP ) kinase both in pituitary cells and in a cell line overexpressing the GHRH receptor
Steinmetz et al., Endocrine 2001 : GHRH rapidly increased p44/p42 MAPK activity in GH3 cells in a protein kinase A-dependent and a protein kinase C-independent manner and stimulated the activation of the transcription factor Elk-1 ... By contrast, GHRH-RP and p75-92NH2 had no effect on p44/p42 MAPK phosphorylation in these cells ... These are the first studies to demonstrate the activation of Elk-1 by GHRH and the activation of p38 MAPK and CHOP by GHRH, GHRH-RP, and p75-92NH2
Siriwardana et al., Mol Endocrinol 2006 (Breast Neoplasms) : In addition, phosphorylation of MAPK was rapidly stimulated by GHRH ... Finally, pretreatment of cells with the somatostatin analog, BIM23014, also prevented GHRH induced MAPK phosphorylation and cell proliferation