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El Messaoudi et al., Proc Natl Acad Sci U S A 2006
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E2F dependent regulation of the CCNE1 promoter was shown to correlate with changes in the level of H3-K9 acetylation/methylation of nucleosomal histones positioned at the transcriptional start site region
Duronio et al., Genes Dev 1995
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Instead, cyclin E expression activates E2F in the CNS
Chiarugi et al., Cell Mol Biol Res 1994
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Notably, both of the two giant regulators of checkpoint 1 ( i.e., p105RB [ retinoblastoma oncosuppressor encoded protein ] and p53 dependent WAF1/CIP1 ) are influenced by or influence G1 cyclins : cyclin E/cdk2 kinase complexes hyperphosphorylate p105RB, induce E2F release, and free G1 exit