UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to CCNB1

CCNB1 — ESPL1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Bind_translation Interaction: CCNB1 — ESPL1 (coimmunoprecipitation) Gorr et al., Mol Cell 2005 *
IRef Intact Interaction: Complex of 17 proteins (association, tandem affinity purification) Hutchins et al., Science 2010
IRef Intact Interaction: Complex of C1QBP-CCNB1-ESPL1-CDK1-PTTG1 (physical association, tandem affinity purification) Hutchins et al., Science 2010

Text-mined interactions from Literome

Holland et al., J Cell Sci 2006 : Separase , the cysteine protease that cleaves cohesin and thereby triggers chromosome disjunction, is inhibited by both securin- and phosphorylation dependent cyclin B1 binding ... Using a novel phosphorylation-specific antibody, we show that mitotic-specific phosphorylation of human separase on S1126 is required to establish, but not maintain, cyclin B1 binding
Jiang et al., Clin Cancer Res 2011 (Ovarian Neoplasms) : Both securin and cyclin B1/CDK1 complex were involved in regulating separase by iASPP