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CASP6 — HSPD1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lin et al., Circulation 2001
(Myocardial Ischemia...) :
We wanted to determine whether
HSP60 and HSP10 could exert a protection against simulated ischemia and reoxygenation ( SI/RO ) -induced apoptotic cell death and whether such protection
results from decreased mitochondrial cytochrome c release and
caspase-3 activation and from the preservation of ATP levels by preservation of the electron transport chain complexes
Zhang et al., Exp Cell Res 2004
:
Effects of UV radiation and exogenous
hsp60 on phosphorylation of MAPKs and on activation of
caspase 3 were examined by Western blot analysis
Chandra et al., J Biol Chem 2007
(Breast Neoplasms...) :
Cytosolic accumulation of
HSP60 during apoptosis with or without apparent mitochondrial release : evidence that its pro-apoptotic or pro-survival functions
involve differential interactions with
caspase-3
Kim et al., Bone 2009
(Bone Resorption) :
Consistent with these observations,
HSP60 activated
caspase-3 and -9, but not caspase-8 in HS-5 cells, and increased the release of mitochondrial cytochrome c into the cytosol ... Furthermore, Western blotting showed that HSP60 up-regulated TLR-2 and TLR-4 expression, and pretreatment with blocking antibodies for TLR-2 and TLR-4 almost completely eliminated the
effects of
HSP60 on apoptosis,
caspase-3 and -9 activation, and activation of NFkappaB and p38 MAPK