Gene interactions and pathways from curated databases and text-mining

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GTF2B — TAF7

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Shakkottai et al., J Biol Chem 2001 : By replacing Met ( 7 ) in the RXCQ motif of Lei with the shorter, unnatural, positively charged diaminobutanoic acid (Dab), we generated Lei-Dab ( 7 ), a selective SKCa2 inhibitor ( K ( d ) = 3.8 nm ) that interacts with residues in the external vestibule of the channel
Kubo et al., Neurosci Res 2002 : These precise patterns of neuronal alignment are regulated by an extracellular matrix protein Reelin , and binding of Reelin to its receptors induces tyrosine phosphorylation of the intracellular adaptor protein disabled 1 (Dab1)
Bock et al., J Biol Chem 2003 : Reelin signaling requires activation of Src family kinases as well as tyrosine phosphorylation of the intracellular adaptor protein Disabled-1 (Dab1)
Tatro et al., Cancer Res 1992 (Melanoma...) : DAB389-MSH inhibited binding of 125I-NDP-MSH to experimental murine B16-F1C23 melanoma metastasis tissue and to melanoma metastases of three patients ... DAB389-MSH inhibited binding of 125I-NDP-MSH to experimental murine B16-F1C23 melanoma metastasis tissue and to melanoma metastases of three patients ... In both mouse and human melanoma tissues, concentration-response relationships for DAB389-MSH mediated inhibition of 125I-NDP-MSH binding were parallel, and its maximal effects were comparable in magnitude, to those of NDP-MSH and alpha-MSH ... In both mouse and human melanoma tissues, concentration-response relationships for DAB389-MSH mediated inhibition of 125I-NDP-MSH binding were parallel, and its maximal effects were comparable in magnitude, to those of NDP-MSH and alpha-MSH
Strasser et al., Mol Cell Biol 2004 : Reelin binding to apolipoprotein E receptor 2 (ApoER2) and very-low-density-lipoprotein receptor ( VLDLR ) leads to phosphorylation of disabled 1 (Dab1) , an adaptor protein which associates with the intracellular domains of both receptors
Prunier et al., J Biol Chem 2005 : Disabled-2 (Dab2) is required for transforming growth factor beta induced epithelial to mesenchymal transition ( EMT )
Sato et al., Glycobiology 2005 (Carcinoma, Embryonal) : Glucosylceramide synthase inhibitors ( d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol [ d-PDMP ] and its analog ) depleted gangliosides and this resulted in delayed expression of Disabled-2 (Dab-2) , suggesting the involvement of gangliosides in F9 cell differentiation
Mpari et al., J Integr Neurosci 2005 : Differential effects of two blockers of small conductance Ca2+ activated K+ channels, apamin and lei-Dab7 , on learning and memory in rats
Jiang et al., Oncogene 2008 (Carcinoma, Embryonal) : The inhibitory effects of Disabled-2 (Dab2) on Wnt signaling are mediated through Axin
Diwakar et al., Biochem Biophys Res Commun 2008 (MAP Kinase Signaling System) : The adaptor phosphoprotein Disabled-2 (Dab2) is known to interact with the cytoplasmic tail of megalin and may be involved in albumin mediated MAPK signalling ... The adaptor phosphoprotein Disabled-2 (Dab2) is known to interact with the cytoplasmic tail of megalin and may be involved in albumin mediated MAPK signalling
Li et al., Cancer Lett 1991 (Carcinoma, Hepatocellular...) : The rates of ras activation were thus very low for both AAF- and 3'-Me-DAB induced rat HCCs , the results thus extending and confirming the findings indicating that ras activation in rat HCCs induced by various type of carcinogens is infrequent
Takahashi et al., J Biol Chem 2009 : These findings identify an unexpected role for the HNF4alpha DNA binding domain in mediating key regulatory interactions and provide new insights into the roles of HNF4alpha and TFIID in RNA polymerase II transcription
Elmlund et al., Structure 2009 : The general transcription factor IID (TFIID) is required for initiation of RNA polymerase II-dependent transcription at many eukaryotic promoters
Phillips et al., Cell Immunol 2010 (Encephalomyelitis, Autoimmune, Experimental...) : DAB ( 389 ) IL-2 also significantly reduced the number of CD4 ( + ), CD8 ( + ), CD25 ( + ), TCRgammadelta ( + ) phenotype and CD11b ( + ) macrophages/microglia within spinal cord lesions ... DAB ( 389 ) IL-2 also significantly reduced the number of CD4 ( + ), CD8 ( + ), CD25 ( + ), TCRgammadelta ( + ) phenotype and CD11b ( + ) macrophages/microglia within spinal cord lesions ... DAB ( 389 ) IL-2 also significantly reduced the number of CD4 ( + ), CD8 ( + ), CD25 ( + ), TCRgammadelta ( + ) phenotype and CD11b ( + ) macrophages/microglia within spinal cord lesions ... DAB ( 389 ) IL-2 also significantly reduced the number of CD4 ( + ), CD8 ( + ), CD25 ( + ), TCRgammadelta ( + ) phenotype and CD11b ( + ) macrophages/microglia within spinal cord lesions
Medvedeva et al., Tsitologiia 1978 : The hepatospecific carcinogen 4-dimethylaminoazobenzene (DAB) , applied as a single interperitoneal injection, induced no changes in the activity of mitochondrial and cytoplasmic malate-dehydrogenase in the rat liver
Chen et al., J Biol Chem 2012 : In addition, both reelin and apoE3 significantly increased phosphorylated disabled-1 (Dab1) , phosphatidylinositol 3-kinase (PI3K), protein kinase C? ( PKC? ), and specificity protein 1 (Sp1) ... In addition, both reelin and apoE3 significantly increased phosphorylated disabled-1 (Dab1) , phosphatidylinositol 3-kinase (PI3K), protein kinase C? ( PKC? ), and specificity protein 1 (Sp1)
Wagner et al., J Virol 2013 : Affinity purification experiments demonstrated that d3-10 ICP4 was not found in complexes with components of TFIID and mediator, suggesting that the defect in RNA polymerase II (Pol II) recruitment was the result of ablated interactions between d3-10 and TFIID and mediator
Martinez-Pacheco et al., Arch Microbiol 1989 : Diamino butanone (DAB) , a competitive inhibitor of ornithine decarboxylase (ODC) a key enzyme in polyamine biosynthesis, inhibited the yeast to hyphae transition in Mucor rouxii, induced by transfer from anaerobiosis to aerobiosis, but not the opposite phenomenon
Fiala et al., J Natl Cancer Inst 1980 (Hyperplasia...) : We concluded that DSF 1 ) did not interfere with 3'-Me-DAB induced proliferation of preneoplastic cells and the increase in GT-ase associated with this reversible adaptation to the influx of 3'-Me-DAB ; and 2 ) inhibited malignant transformation and, consequently, prevented the formation and proliferation of neoplastic cells and the increase in constitutive GT-ase related to neoplasia
Dent et al., Carcinogenesis 1982 (Liver Neoplasms...) : Both DEN and DAB caused increases in epoxide hydrolase but classical sigmoidal dose-response curves were not obtained
Ramadan et al., Cell Immunol 1995 (Granuloma...) : DAB389IL-2 suppressed IL-2 , lectin mitogen ( Con A ), and soluble Schistosoma mansoni egg antigen induced lymphocyte proliferation and in vitro granuloma formation
Goodrich et al., Cell 1993 : Enhancement of RNA polymerase II transcription by the viral transactivator VP16 requires the TFIID complex , which consists of the TATA binding protein (TBP) and TBP associated factors (TAFs)
Weinzierl et al., EMBO J 1993 : Regulation of transcription initiation by RNA polymerase II requires TFIID , a multisubunit complex composed of the TATA binding protein (TBP) and at least seven tightly associated factors ( TAFs )
Bousvaros et al., Dig Dis Sci 1997 : DAB389IL-2 ( 10 ( -12 ) M ) also significantly reduced the numbers of activated helper T cells and IFN-gamma levels in 24-hr cultures
Lambert de Rouvroit et al., Biochem Pharmacol 1998 : The response of cortical plate cells to reelin requires the tyrosine kinase adaptor disabled-1 (Dab1)