Gene interactions and pathways from curated databases and text-mining

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IL2 — IRS1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Kim et al., J Biol Chem 2005 (Inflammation) : In addition, using a phospho-specific antibody against IRS-1 phosphorylated at Ser ( 24 ), we found that interleukin-1 or TNF-alpha treatment of Fao cells stimulated increased phosphorylation of endogenous IRS-1 at Ser ( 24 )
Johnston et al., J Biol Chem 1995 : We report here that IL-2 , IL-7, and IL-15, as well as IL-4, rapidly stimulate the tyrosine phosphorylation of IRS-1 and IRS-2 in human peripheral blood T cells, NK cells, and in lymphoid cell lines ... We further demonstrate that the p85 subunit of phosphoinositol 3-kinase associates with IRS-1 in response to IL-2 and IL-4 in T cells