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HSPG2 — PRKCA

Text-mined interactions from Literome

Capiati et al., J Cell Biochem 2000 (Calcium Signaling) : Neomycin, a phospholipase C (PLC) inhibitor, blocked its effects on [ Ca ( 2+ ) ] ( i ), PKC activity, and translocation of PKC alpha
Xu et al., J Biol Chem 2001 : Overexpression of either a PLC beta1 mutant in which the PKC phosphorylation site Ser ( 887 ) was replaced by alanine, or a dominant negative PKC alpha , resulted in a sustained activation of nuclear PLC following IGF-I stimulation
Marino et al., J Cell Physiol 2001 (Breast Neoplasms...) : The PLC inhibitors, neomycin and U73,122, and PKC-alpha down regulator , phorbol 12-myristate 13-acetate ( PMA ), were able to prevent estradiol induced DNA synthesis in hepatoma cells, but ineffective in mammary cells ; wortmannin, an inhibitor of phosphoinositide 3-kinases (PI3-K), blocked DNA synthesis in both cell lines
Munakata et al., Ann Thorac Surg 2002 (Myocardial Ischemia) : PI-PLC inhibition prevented the ischemic translocation of PKC-alpha , PKC-epsilon, and PKC-eta, and impaired cardiac recovery and cytosolic calcium regulation without significant changes in energy metabolism
Ramnath et al., Br J Pharmacol 2008 : SP-induced chemokine production in pancreatic acinar cells resulted from PLC induced elevated intracellular calcium and PKCalpha/betaII activation, subsequently leading to the activation of MAPKinases ( ERK and JNK ) and transcription factors NF-kappaB and AP-1
Khundmiri et al., American journal of physiology. Renal physiology 2008 : In the present work utilizing opossum kidney cells, a model of renal proximal tubule, PTH stimulated ERK phosphorylation and membrane translocation of PKCalpha were prevented by inhibition of Src kinase, PLC , and calcium entry