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HMOX1 — PRKAA1

Text-mined interactions from Literome

Lin et al., Am J Pathol 2010 (Drug-Induced Liver Injury...) : Herein, we show that the deleterious effects of iron dextran on liver function and iron deposition were significantly reversed by adiponectin gene therapy, which was accompanied by AMP activated protein kinase (AMPK) phosphorylation and heme oxygenase (HO)-1 induction
Liu et al., Am J Physiol Heart Circ Physiol 2011 : Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival ... The present study determined whether AMP activated protein kinase (AMPK) regulates heme oxygenase (HO)-1 gene expression in endothelial cells ( ECs ) and if HO-1 contributes to the biological actions of this kinase ... In conclusion, AMPK stimulates HO-1 gene expression in human ECs via the Nrf2/antioxidant responsive element signaling pathway
Wang et al., Naunyn Schmiedebergs Arch Pharmacol 2011 : In this study, we also, for the first time, demonstrated that AMP activated protein kinase (AMPK) can mediate HO-1 expression via the downstream activation of p38 and Akt
Kim et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011 : We investigated whether AMP activated protein kinase (AMPK) activation induced by heme oxygenase-1 (HO-1) is a mediator of the beneficial effects of cilostazol and whether cilostazol may prevent cell proliferation and reactive oxygen species ( ROS ) production by activating AMPK in VSMC ... Cilostazol also significantly decreased platelet derived growth factor ( PDGF ) -induced VSMC proliferation and ROS production by activating AMPK induced by HO-1
Wu et al., PloS one 2012 : Together, these results demonstrate that OA-NO ( 2 ) activates AMPK in endothelial cells via an HO-1 dependent mechanism that increases HIF-1a protein expression and Ca ( 2+ ) /CaMKKß activation
Jang et al., Br J Pharmacol 2013 (Wounds, Penetrating) : Moreover, CKD712 decreased HO-1 expression without affecting the expression of p-AMPK by siHO-1 transfection, but it failed to induce HO-1 in siAMPKa1 transfected cells, suggesting that AMPK is involved in HO-1 induction by CKD712 in HDFs
Byun et al., Journal of clinical biochemistry and nutrition 2013 : It has been reported that pharmacological activation of AMPK induces heme oxygenase-1 (HO-1) expression ... Here we examined whether AMPK activation by BL would be linked to HO-1 expression in RAW264.7 macrophages and whether HO-1 expression could mediate the anti-inflammatory effects of BL. BL treatment induced concentration- and time dependent AMPK phosphorylation and HO-1 expression