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HMOX1 — NOX5

Text-mined interactions from Literome

Ryter et al., Antioxid Redox Signal 2002 (MAP Kinase Signaling System) : Diphenylene iodonium, an inhibitor of NADPH oxidase , also induced the expression of HO-1 in PAEC under both normoxia and hypoxia
Wijayanti et al., J Biol Chem 2005 (Inflammation) : Heme oxygenase-1 gene activation by the NAD ( P ) H oxidase inhibitor 4- ( 2-aminoethyl ) benzenesulfonyl fluoride via a protein kinase B, p38 dependent signaling pathway in monocytes ... Because HO-1 is up-regulated by NAD ( P ) H oxidase activators such as lipopolysaccharide and 12-O-tetradecanoylphorbol-13-acetate in monocytic cells, we investigated the gene regulation of HO-1 by the chemical NAD ( P ) H oxidase inhibitor 4- ( 2-aminoethyl ) benzenesulfonyl fluoride ( AEBSF )
Jiang et al., Hypertension 2006 : Moreover, the heme oxygenase-1 end product bilirubin directly inhibited fully functional NADPH oxidase and seemed to interrupt the assembly and activation of the oxidase
Datla et al., Hypertension 2007 : The increase in HO-1 activity and inhibition of NADPH oxidase activity by hemin were reversed by tin protoporphyrin-IX and were not associated with changes in Nox2 or Nox4 protein levels
Cooper et al., Free Radic Biol Med 2009 (Cell Transformation, Neoplastic...) : Furthermore, arsenite induced, but not UVA induced, p38 activation and HO-1 expression were dependent upon NADPH oxidase activity
Churchman et al., J Cell Mol Med 2009 : Inhibition of NAD ( P ) H oxidase or scavenging of superoxide diminished HO-1 induction in response to TGF-beta(1)
Tung et al., J Cell Physiol 2011 (Neuroblastoma) : Consistently, overexpression of HO-1 attenuated EV71 induced NADPH oxidase/ROS generation and EV71 replication which were abrogated by pretreatment with an HO-1 inhibitor, zinc protoporphyrin IX ( ZnPP IX )
von Knethen et al., Free Radic Biol Med 2011 : NADPH oxidase activation in either RAW264.7 cells or peritoneal macrophages ( PM ) derived from PPAR? wild-type mice increased reactive oxygen species ( ROS ) formation, caused PPAR? activation, heme oxygenase-1 (HO-1) induction, and concomitant IFN-ß expression
Singh et al., Cancer 2012 (Blast Crisis...) : Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia
Oh et al., Phytother Res 2013 : SRE also abolished 6-OHDA induced ROS by inhibiting NOX expression and by inducing HO-1 expression via NF-E2 related factor-2 activation
He et al., Invest Ophthalmol Vis Sci 2013 (Diabetic Retinopathy...) : In vitro retina explants culture was used to assess the role of NADPH oxidase in high glucose induced HO-1 expression ... The NADPH oxidase inhibitors apocynin and DPI significantly blocked the HO-1 expression that was induced by high glucose levels in cultured retina explants ... The expression patterns of HO-1, Nox2, Nox4 in db/db mouse retinas, and the suppressive effects of NADPH oxidase inhibitors on the expression of HO-1 induced by high glucose levels in cultured retina explants suggest that the expression of HO-1 is, at least partially, mediated by NADPH oxidase in this diabetic animal model