Gene interactions and pathways from curated databases and text-mining

◀ Back to ERCC2

CCNH — ERCC2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Chen et al., Mol Cell Biol 1999 : Recent reports have shown that Tat can also interact with the multisubunit transcription factor TFIIH complex and increase the phosphorylation of CTD by the Cdk activating kinase (CAK) complex associated with the core TFIIH
Vandel et al., EMBO J 1999 : We demonstrate that TFIIH is responsible for the E2F-1 phosphorylation observed in cell extracts and that endogenous E2F-1 interacts in vivo with p62, a component of TFIIH, during S phase ... These results suggest that TFIIH mediated phosphorylation of E2F-1 plays a role in triggering E2F-1 degradation during S phase
Sakurai et al., Biochem Biophys Res Commun 1999 : In the transcription process, TFIIE regulates TFIIH kinase activity that phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II
Kim et al., Mol Cell Biol 1999 : We showed that hnRNP U can bind TFIIH in vivo under certain conditions and inhibit TFIIH mediated CTD phosphorylation in vitro ... The abilities of hnRNP U to inhibit TFIIH mediated CTD phosphorylation and its Pol II association are necessary for hnRNP U to mediate the repression of Pol II elongation ... Based on these observations, we suggest that a subfraction of hnRNP U, as a component of the Pol II holoenzyme, may downregulate TFIIH mediated CTD phosphorylation in the basal transcription machinery and repress Pol II elongation
Spåhr et al., J Biol Chem 2000 : This stimulation was species-specific, because S. pombe Mediator could not stimulate TFIIH purified from S. cerevisiae
Yokoi et al., J Biol Chem 2000 : Interestingly, association of TFIIH with DNA was observed in both wild-type and XP-A cell extracts but not in XP-C cell extracts, and XPC-HR23B could restore the association of TFIIH with DNA in XP-C cell extracts ... Interestingly, association of TFIIH with DNA was observed in both wild-type and XP-A cell extracts but not in XP-C cell extracts, and XPC-HR23B could restore the association of TFIIH with DNA in XP-C cell extracts ... Moreover, we found that XPC-HR23B was necessary for efficient association of TFIIH with damaged DNA in cell-free extracts ... Moreover, we found that XPC-HR23B was necessary for efficient association of TFIIH with damaged DNA in cell-free extracts
Watanabe et al., Genes Cells 2000 : In addition, TFIIH phosphorylation of PolII was stimulated by TFIIE both in solution and during preinitiation complex formation, whereas Cdk7/Cyclin H and CAK phosphorylation of PolII was not
Wada et al., Mol Cell 2000 : We find that the kinase activity of TFIIH is dispensable for this activity, demonstrating that TFIIH mediated CTD phosphorylation is not involved in the regulation of FACT and DSIF/NELF activities
Yamamoto et al., Mol Cell Biol 2001 : Here we demonstrate for the first time that TFIIH mediated phosphorylation of RNA polymerase II (Pol II) is essential for the transition to elongation
Winkler et al., Biochemistry 2001 : Furthermore, we reveal that TFIIH inhibits the structure-specific endonuclease activities of both XPG and ERCC1-XPF , responsible for the 3 ' and 5 ' incision in NER, respectively ... Furthermore, we reveal that TFIIH inhibits the structure-specific endonuclease activities of both XPG and ERCC1-XPF , responsible for the 3 ' and 5 ' incision in NER, respectively
Zhou et al., J Biol Chem 2001 : TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription ... The presence of TFIIH in the HIV-1 preinitiation complex inhibits CDK9 phosphorylation
Braddock et al., Nature 2002 : FBP bound to FUSE acts through TFIIH at the promoter
Brabazon et al., Biochim Biophys Acta 2002 : Cyclin dependent kinase 8 (cdk8) regulates transcription by phosphorylating RNA polymerase II and TFIIH
Sakurai et al., Genes Cells 2003 : By using a chromatin immunoprecipitation technique, we found that TFIIE is necessary for stable binding of TFIIH and RNAPII to the ADH1 promoter, whose activation requires TFIIE ... However, binding of TFIIH and RNAPII to CUP1 upon its activation did not require TFIIE
Chen et al., Nature 2003 : Excess Xpd titrates CAK activity, resulting in decreased Cdk T-loop phosphorylation, mitotic defects and lethality, whereas a decrease in Xpd results in increased CAK activity and cell proliferation
Zurita et al., Trends Genet 2003 : Interpretation of the phenotypes produced by mutations in TFIIH is complicated by the recent finding that TFIIH plays a role in RNA polymerase I ( RNA Pol I ) -mediated transcription
Mason et al., Mol Cell Biol 2003 : In Saccharomyces cerevisiae cells, FACT specifically associates with active Pol II genes in a TFIIH dependent manner and travels across the gene with elongating Pol II
Guidi et al., J Biol Chem 2004 : Mediator does not stimulate the activity of several other CTD kinases, suggesting that the specific enhancement of TFIIH kinase activity results in Kin28 being the primary CTD kinase at initiation
Fukuda et al., Mol Cell Biol 2004 : Furthermore, PC4 displayed physical interactions with both TFIIH and GAL4-VP16 through its coactivator domain, and these interactions were regulated distinctly by PC4 phosphorylation
Drané et al., Mol Cell 2004 : Selective regulation of vitamin D receptor-responsive genes by TFIIH
Brondani et al., Biochem Biophys Res Commun 2005 : The transcription factor TFIIH mediates phosphorylation of the retinoic acid receptor alpha (RARalpha) at position Ser77
Giglia-Mari et al., PLoS Biol 2006 : Transcription/repair factor IIH (TFIIH) is essential for RNA polymerase II transcription and nucleotide excision repair ( NER )
Kim et al., EMBO J 2006 : Upon stimulation of the cells by TNF-alpha , NF-kappaB and TFIIH are rapidly recruited to the promoter together with additional Mediator and RNAP II, but CDK8 is lost
Okuda et al., EMBO J 2008 : Among the GTFs, TFIIE recruits TFIIH to complete the PIC formation and regulates enzymatic activities of TFIIH
Bruck et al., EMBO J 2009 : We demonstrate that MSK1 phosphorylates RARalpha at S369 located in the ligand binding domain, allowing the binding of TFIIH and thereby phosphorylation of the N-terminal domain at S77 by cdk7/cyclin H ... We demonstrate that MSK1 phosphorylates RARalpha at S369 located in the ligand binding domain, allowing the binding of TFIIH and thereby phosphorylation of the N-terminal domain at S77 by cdk7/cyclin H ... Finally, the phosphorylation cascade initiated by MSK1 controls the recruitment of RARalpha/TFIIH complexes to response elements and subsequently RARalpha target gene activation
Ohkuma et al., Mol Cell Biol 1995 : The general transcription factor TFIIE recruits TFIIH at a late stage of transcription initiation complex formation and markedly stimulates TFIIH dependent phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase II ... To study this function of TFIIE in more detail, systematic deletion mutations were introduced into the large subunit of TFIIE ( TFIIE-alpha ) and were analyzed with regard to their effects on TFIIH dependent CTD phosphorylation, TFIIE dependent basal and enhancer dependent transcription, and interactions of TFIIE-alpha with both TFIIE-beta and TFIIH
Dvir et al., J Biol Chem 1996 : A role for ATP and TFIIH in activation of the RNA polymerase II preinitiation complex prior to transcription initiation
Drapkin et al., Proc Natl Acad Sci U S A 1996 : We present evidence proposing a critical role for ERCC2 in mediating the association of CAK with core TFIIH subunits ... We present evidence proposing a critical role for ERCC2 in mediating the association of CAK with core TFIIH subunits
Parada et al., Nature 1996 : Here we show that Tat enhanced HIV-1 transcription in vitro requires both TFIIH and the CTD of Pol II ... Under conditions that jointly restrict transcriptional elongation and TFIIH mediated CTD phosphorylation, Tat stimulates both these activities ... Thus, stimulation of Pol II elongation by Tat may involve direct effects on TFIIH mediated CTD phosphorylation
Dvir et al., Proc Natl Acad Sci U S A 1997 : In this report, we present direct evidence that TFIIH also controls RNA polymerase II activity at a postinitiation stage of transcription, by preventing premature arrest by very early elongation complexes just prior to their transition to stably elongating complexes
Yokomori et al., Proc Natl Acad Sci U S A 1998 : These studies suggest an alternative PIC assembly pathway in which TFIIE affects both TBP and TFIIH functions during initiation of RNA synthesis
Okamoto et al., J Biol Chem 1998 : In addition, we analyzed the effects of the TFIIEbeta deletion mutations on TFIIH dependent phosphorylation of the C-terminal domain of RNA polymerase II and on wild type TFIIEbeta-driven basal transcription