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CREB1 — CREM

Pathways - manually collected, often from reviews:

• FastForward regulation: CREB1 → CREM (transcriptional regulation, unknown) Zhang et al., Proc Natl Acad Sci U S A 2005
  Evidence: DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: CREB1 — CREM (in vivo) Walker et al., Proc Natl Acad Sci U S A 1994*
• IRef Hprd Interaction: CREB1 — CREM (in vitro) Walker et al., Proc Natl Acad Sci U S A 1994*
• IRef Ophid Interaction: CREB1 — CREM (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: CREB1 — CREM (aggregation, confirmational text mining) Walker et al., Proc Natl Acad Sci U S A 1994*

Text-mined interactions from Literome

Wang et al., Mol Cell Biochem 2000 : Although CREB transcription is activated by multiple classes of agonists in VSMC, and ICER can inhibit agonist induced transcription mediated by both CREB and AP-1 enhancers, these transcription factors are not obligate components of the pathways regulating AT1-R gene expression in rat VSMC
Don et al., Mol Cell Endocrinol 2002 : Inducible cAMP early repressor (ICER) , a suppressor isoform of CREM, also activated by CREB, down regulates CREB expression together with its own expression, resetting CREB to basal level that enables a new spermatogenic wave
Mouravlev et al., Brain Res 2007 : Here we found that transient expression of a CREB dominant interfering mutant A-CREB or the inducible cAMP early repressor, ICER , led to the dramatic decrease of exogenously co-expressed CREB in 293 human embryonic kidney cells ... Hence, heterodimerization of unphosphorylated CREB with either A-CREB or ICER triggers CREB protein degradation, whereas phosphorylation prevents CREB from such degradation both in vitro and in vivo
Steinbicker et al., Nitric Oxide 2011 : Expression of a dominant negative CREB in RPaSMC prevented the NO-mediated induction of CRE dependent gene transcription and ICER gene expression ... Our results suggest that induction of ICER gene expression by NO requires both CREB phosphorylation and Ca ( 2+ ) signaling
Favre et al., Diabetes 2011 (Obesity) : In this study, we investigated whether impaired expression of the inducible cAMP early repressor (ICER) , a transcriptional antagonist of CREB, is responsible for the increased CREB activity in adipocytes of obese mice and humans
Lamas et al., Mol Endocrinol 1997 : Thus, while phosphorylation of cAMP response element binding protein ( CREB ) by the cAMP dependent protein kinase A is the prerequisite for induction, it has been proposed that the following attenuation involves both CREB dephosphorylation and repression by the inducible repressor ICER
Monaco et al., Oncogene 1997 : Both CREB phosphorylation and ICER inducibility require an intact Ras dependent signalling pathway
Walker et al., Mol Cell Endocrinol 1998 : We suggest that the expression of ICER in Sertoli cells may contribute to the periodic repression of CREB gene expression during the repeated 12-day cycles of spermatogenesis, and may be required to reset the levels of activator CREB prior to the initiation of each new cycle of spermatogenesis