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CD79B — GRB2
Pathways - manually collected, often from reviews:
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
Reactome Reaction:
CD79B
→
GRB2
(reaction)
Watanabe et al., Biochem Biophys Res Commun 2000, Engels et al., Eur J Immunol 2001, Kabak et al., Mol Cell Biol 2002, Chiu et al., EMBO J 2002, Oellerich et al., Mol Cell Proteomics 2009, Oellerich et al., EMBO J 2011, Fu et al., J Biol Chem 1997, Fu et al., Immunity 1998, Wienands et al., J Exp Med 1998
-
Reactome Reaction:
CD79B
→
GRB2
(indirect_complex)
Watanabe et al., Biochem Biophys Res Commun 2000, Engels et al., Eur J Immunol 2001, Kabak et al., Mol Cell Biol 2002, Chiu et al., EMBO J 2002, Oellerich et al., Mol Cell Proteomics 2009, Oellerich et al., EMBO J 2011, Fu et al., J Biol Chem 1997, Fu et al., Immunity 1998, Wienands et al., J Exp Med 1998
Text-mined interactions from Literome
Harmer et al., J Biol Chem 1999
:
Here, we report that cross linking of the
BCR induces association between
Grb2 and SHIP as well as association between Shc and SHIP
Ingham et al., J Biol Chem 2001
:
Gab1 expression also increased
BCR induced tyrosine phosphorylation of SHP2 as well as the binding of
Grb2 to SHP2
Gaston et al., Exp Hematol 2004
:
In a yeast three-hybrid assay,
Grb2 mediated an interaction between Cbl and
Bcr-Abl that was dependent on a functional Grb2 binding site ...
Grb2 or another, yet unidentified, protein may
mediate an initial interaction between Cbl and
Bcr-Abl that is independent of Cbl tyrosine phosphorylation
Maru et al., Mol Cell Biol 1995
(Cell Transformation, Neoplastic) :
Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases
induces association of
BCR with
GRB-2/SOS ... Tyrosine phosphorylation of
BCR in v-fps transformed cells
induced its association with
GRB-2/SOS , the RAS guanine nucleotide exchange factor complex
Smit et al., Oncogene 1996
(Burkitt Lymphoma) :
B-cell antigen receptor (BCR) stimulation
induces tyrosine phosphorylation of the Shc adaptor protein and its association with
Grb2 ... We reveal here an additional complexity of the
BCR induced
Shc/Grb2 complex : it contains tyrosine phosphorylated proteins of 130, 110 and 75 kDa