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SOCS1 — TLR2
Text-mined interactions from Literome
Bartz et al., Blood 2006
:
The results indicate that
TLR stimulation during the period of DC generation interferes with and deviates DC differentiation and that these effects are
mediated particularly by
SOCS-1
Srivastava et al., J Biol Chem 2009
(Tuberculosis) :
Co-stimulating DC-SIGNR1 and
TLR2 differentially
regulates SOCS1 expression depending on the relative concentration of their ligands ... Stimulating DC-SIGNR1 with M. tb infection increases SOCS1 expression, while stimulating
TLR2 with M. tb infection
reduces SOCS1 expression ... These results indicate that
TLR2 and DC-SIGNR1 differentially
regulate SOCS1 expression during M. tb infection
Srivastava et al., Immunol Cell Biol 2011
(Tuberculosis) :
We recently demonstrated that
toll-like receptor 2 and dendritic cell (DC)-SIGNR1 differentially
regulate SOCS1 expression in DCs during M. tuberculosis infection
Tajiri et al., J Immunol 2012
(Autoimmune Diseases...) :
Suppressor of cytokine signaling
(SOCS) 1 plays a key role in the negative regulation of both
TLR- and cytokine receptor mediated signaling, which is involved in innate immunity and subsequent adaptive immunity