◀ Back to SOCS1
IRS2 — SOCS1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Rui et al., J Biol Chem 2002
(Insulin Resistance) :
Adenoviral mediated expression of
SOCS1 in mouse liver dramatically
reduced hepatic IRS1 and
IRS2 protein levels and caused glucose intolerance ; by contrast, expression of the SOCS1 mutants had no effect
Ueki et al., Mol Cell Biol 2004
(Endotoxemia...) :
Direct overexpression of SOCS-3 in liver by adenoviral mediated gene transfer markedly decreases tyrosine phosphorylation of both IRS-1 and IRS-2, while
SOCS-1 overexpression preferentially
inhibits IRS-2 phosphorylation
Jamieson et al., J Biol Chem 2005
(Hypoglycemia...) :
Socs1 deficiency
increases IRS-2 expression and enhances hepatic insulin sensitivity in vivo indicating that inhibition of SOCS1 may be a logical strategy in type 2 diabetes