UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

CD40 — SOCS1

Text-mined interactions from Literome

Wesemann et al., J Immunol 2002 : Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages ... We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation, which also then results in suppression of IFN-gamma induced TNF-alpha secretion and subsequent NF-kappaB activation
Qin et al., FASEB J 2006 : IFN-beta induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia ... The ectopic expression of SOCS-1 abrogates IFN-beta mediated STAT-1alpha activation and inhibits IFN-beta induced CD40 expression ... These novel results indicate that IFN-beta induced SOCS-1 plays an important role in the negative regulation of IFN-beta induced CD40 gene expression