Inaba et al., Biochem Biophys Res Commun 2005
:
Additionally, SOCS1 augmented MEK phosphorylation and reduced Akt phosphorylation induced by IGF-I
Emberley et al., Cancer Res 2005
(Breast Neoplasms) :
Structural analysis by three-dimensional protein modeling, immunoprecipitation, and yeast two-hybrid assay and functional analysis using transfected reporter gene and Western blot assays revealed that the in vitro effects of S100A7 on phospho-Akt and the nuclear factor-kappaB pathway are dependent on the Jab1 binding site and the interaction with Jab1 Tortorella et al., J Gerontol A Biol Sci Med Sci 2006
:
These results indicate that defective PI3-K/Akt/ERK1/2 activation, likely dependent on elevated SOCS1 and SOCS3 levels, may affect the GM-CSF capacity to delay neutrophil apoptosis in elderly persons
Venieratos et al., Cell Signal 2010
:
Inhibition of SOCS-1 expression by SOCS-1-specific small interfering RNA restored IRS-2/PI3K mediated Akt phosphorylation suppressed by high glucose