UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

PARP1 — VIP

Text-mined interactions from Literome

Alleaume et al., Neuropeptides 2003 : We also demonstrated that VIP induced phosphorylation of the small GTPase Rap1 in these cancerogenous cells ... Furthermore, VIP induced the activation of the small GTPase Rap1 and of a 95 kDa isoform of the serine/threonine kinase B-Raf
Romano et al., J Biol Chem 2003 : By using pull-down experiments, we show that VIP and PACAP38 preferentially activate Rap1 , whereas thyrotropin releasing hormone (TRH) and epidermal growth factor (EGF) mainly activate Ras GTPase
Fernández et al., J Mol Endocrinol 2005 : Studies in GH4C1 cells, with an expression vector for Rap1 GTPase activating protein ( Rap1 GAP1 ), demonstrated reduced VIP induced MAPK activation, indicating that VIP dependent activation of the extracellular signal regulated kinase ( ERK ) pathway requires PKA-Rap1 signaling
Hilairet et al., Neuropeptides 1998 : In these cells, VIP induces Rap 1 phosphorylation and a yet unidentified modification that leads to their acidification