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EGR1 — WT1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
McCoy et al., Cell Growth Differ 1999
(Wilms Tumor) :
Inhibition is likely a direct effect of WT1 binding to the MDR1 promoter because : ( a )
WT1 expression does not
inhibit the increase in
EGR1 after TPA treatment ; ( b ) inhibition by WT1 requires the zinc finger domain ; ( c ) WT1 binds to MDR1 promoter sequences that bind EGR1 and are responsive to TPA ; and ( d ) there is an inverse correlation between WT1 protein expression and MDR1 expression and promoter activity
Rackley et al., J Urol 1995
:
Transient transfection experiments have shown that
WT1 can
repress EGR-1 activated transcription from the EGR-1 promoter
Reddy et al., J Biol Chem 1995
:
We found that the transcriptional
effect of
WT1 on the
Egr1 promoter could be modulated by the use of expression vectors containing different promoters ...
WT1 activated the
Egr1 promoter when expression of WT1 was driven by the Rous sarcoma virus promoter