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EGR1 — LPA

Text-mined interactions from Literome

Iyoda et al., J Biol Chem 2012 (MAP Kinase Signaling System) : Previously, we reported that a transcriptional mechanism controls LPA induced expression of Egr-1 in vascular smooth muscle cells ... In this study, we determined the essential intracellular signaling pathway leading to LPA induced Egr-1 expression ... Our data demonstrate that activation of ERK1/2 and JNK, but not p38 MAPK, is required for LPA induced Egr-1 expression in smooth muscle cells ... Examining the upstream kinases that mediate ERK and JNK activation, leading to Egr-1 expression, we found that LPA induced activation of MAPKs and expression of Egr-1 are dependent on PKC activation ... Our data reveal an intracellular regulatory mechanism : LPA induction of Egr-1 expression is via LPA cognate receptor ( LPA receptor 1 ) -dependent and PKCd mediated ERK and JNK activation
Windischhofer et al., Biochimie 2012 (MAP Kinase Signaling System...) : LPA induced expression of functional Egr-1 in MG-63 cells could be confirmed by electrophoretic mobility shift assay ... LPA induced Egr-1 upregulation was accompanied by a time dependent decrease of periostin ( previously called osteoblast-specific factor 2 ), a cell adhesion protein for pre-osteoblasts
Reiser et al., Biochem J 1998 : LPA mediated expression of pghs-2 and egr-1 was reduced to base-line levels by toxin B, indicating a role for Rho proteins in LPA mediated gene induction