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CDKN2B — RBBP7
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Hitomi et al., FEBS Lett 2003
:
We report here that
HDAC inhibitors, trichostatin A (TSA) and sodium butyrate,
activate the
p15(INK4b) gene, a member of the INK4 gene family, through its promoter in HaCaT cells
Hitomi et al., FEBS Lett 2007
:
Treatment with a histone deacetylase (HDAC) inhibitor has activated the expression of p15(INK4b) in wild-type MEFs but has no effect in MEFs lacking Oct-1, suggesting that Oct-1 represses
p15(INK4b) gene expression in an
HDAC dependent manner
Matsuzaki et al., Environ Health Prev Med 2005
:
We recently showed that
histone deacetylase (HDAC) inhibitors, promising chemopreventive and chemotherapeutical agents,
induce p15(INK4b) and p19(INK4d) gene expression and cause growth arrest, suggesting that both genes are important molecular targets for HDAC inhibitors