◀ Back to XPO1
RAN — XPO1
Pathways - manually collected, often from reviews:
-
KEGG Ribosome biogenesis in eukaryotes:
RAN
→
XPO1
(protein-protein, binding/association)
-
KEGG RNA transport:
RAN
→
XPO1
(protein-protein, binding/association)
-
KEGG RNA transport:
RAN
→
XPO1
(protein-protein, binding/association)
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
HDAC1 (HDAC1)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, collaborate)
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
HDAC1 (HDAC1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
NPC complex (RANBP2-NUP214-NUP210-NUP62-NUP153)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(translocation, activates)
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
NPC complex (RANBP2-NUP214-NUP210-NUP62-NUP153)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(translocation, activates)
-
NCI Pathway Database FoxO family signaling:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
FOXO1/14-3-3 family complex (FOXO1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
(translocation, activates)
Rena et al., EMBO J 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
HDAC4 (HDAC4)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
HDAC4 (HDAC4)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(modification, collaborate)
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, activates)
Askjaer et al., Mol Cell Biol 1999
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Exportin 1 (XPO1)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, collaborate)
Askjaer et al., Mol Cell Biol 1999
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Exportin 1 (XPO1)
→
Ran/GTP complex (RAN)
(modification, collaborate)
Askjaer et al., Mol Cell Biol 1999
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
Ran/GTP complex (RAN)
(modification, collaborate)
Askjaer et al., Mol Cell Biol 1999
Evidence: assay
-
NCI Pathway Database FoxO family signaling:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
FOXO4/14-3-3 family complex (FOXO4-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
(translocation, activates)
Brownawell et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Role of Calcineurin-dependent NFAT signaling in lymphocytes:
Exportin 1/Ran/NUP214 complex (XPO1-RAN-NUP214)
→
NFATc (NFATC1)
(translocation, activates)
Hutten et al., Mol Cell Biol 2006*, Beals et al., Science 1997*, Kehlenbach et al., J Cell Biol 1998*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Ran/GTP complex (RAN)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, collaborate)
Stade et al., Cell 1997*
Evidence: assay, other species
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Ran/GTP complex (RAN)
→
Exportin 1 (XPO1)
(modification, collaborate)
Stade et al., Cell 1997*
Evidence: assay, other species
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
Exportin 1 (XPO1)
(modification, collaborate)
Stade et al., Cell 1997*
Evidence: assay, other species
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, activates)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(modification, activates)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
SUMO1 (SUMO1)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, collaborate)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
SUMO1 (SUMO1)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(modification, collaborate)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(modification, collaborate)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
SUMO1/HDAC4 complex (SUMO1-HDAC4)
(modification, collaborate)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
→
SUMO1/HDAC4 complex (SUMO1-HDAC4)
(modification, collaborate)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Canonical NF-kappaB pathway:
Exportin 1/RanGTP complex (XPO1-RAN)
→
NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA)
(translocation, activates)
Tam et al., Mol Cell Biol 2000*, Lee et al., J Biol Chem 2001*
Evidence: assay, other species
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
HDAC4 (HDAC4)
(modification, collaborate)
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(modification, collaborate)
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
HDAC4 (HDAC4)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC1 (HDAC1)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC1 (HDAC1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NPC/RanGAP1/SUMO1/Ubc9 complex (RANGAP1-SUMO1-UBE2I-NUP62-RANBP2-NUP210-NUP214-NUP153)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, activates)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NPC/RanGAP1/SUMO1/Ubc9 complex (RANGAP1-SUMO1-UBE2I-NUP62-RANBP2-NUP210-NUP214-NUP153)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, activates)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SUMO1 (SUMO1)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SUMO1 (SUMO1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
SUMO1/HDAC1 complex (SUMO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
→
SUMO1/HDAC1 complex (SUMO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, activates)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, activates)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
SUMO1/HDAC1 complex (SUMO1-HDAC1)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
SUMO1/HDAC1 complex (SUMO1-HDAC1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
SUMO1 (SUMO1)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
SUMO1 (SUMO1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
NPC/RanGAP1/SUMO1/Ubc9 complex (RANGAP1-SUMO1-UBE2I-NUP62-RANBP2-NUP210-NUP214-NUP153)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, activates)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
NPC/RanGAP1/SUMO1/Ubc9 complex (RANGAP1-SUMO1-UBE2I-NUP62-RANBP2-NUP210-NUP214-NUP153)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(modification, activates)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
SUMO1 (SUMO1)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, collaborate)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
SUMO1 (SUMO1)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(modification, collaborate)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
(modification, collaborate)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
SUMO1/HDAC4 complex (SUMO1-HDAC4)
(modification, collaborate)
Kirsh et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class II:
Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4)
→
SUMO1/HDAC4 complex (SUMO1-HDAC4)
(modification, collaborate)
Kirsh et al., EMBO J 2002
Evidence: assay
-
Reactome Reaction:
RAN
→
XPO1
(indirect_complex)
Askjaer et al., J Biol Chem 1998*
-
Reactome Reaction:
RAN
→
XPO1
(direct_complex)
-
Reactome Reaction:
RAN
→
XPO1
(reaction)
Bischoff et al., Proc Natl Acad Sci U S A 1995*, Askjaer et al., J Biol Chem 1998*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RAN
—
XPO1
(physical association, affinity chromatography technology)
Chase et al., PLoS Pathog 2011*
-
IRef Biogrid Interaction:
RAN
—
XPO1
(direct interaction, pull down)
Lipowsky et al., EMBO J 2000*
-
IRef Biogrid Interaction:
RAN
—
XPO1
(colocalization, biochemical)
Havugimana et al., Cell 2012
-
IRef Biogrid Interaction:
RAN
—
XPO1
(physical association, affinity chromatography technology)
Tickenbrock et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
RAN
—
XPO1
(direct interaction, pull down)
Fornerod et al., Cell 1997*
-
IRef Biogrid Interaction:
RAN
—
XPO1
(direct interaction, pull down)
Plafker et al., Mol Cell Biol 2000*
-
MIPS CORUM Snurportin-CRM1-RanGTP complex:
Snurportin-CRM1-RanGTP complex complex (RAN-SNUPN-XPO1)
Paraskeva et al., J Cell Biol 1999*
-
MIPS CORUM CRM1-RAN-PHAX-CBC complex (cap binding complex):
CRM1-RAN-PHAX-CBC complex (cap binding complex) complex (NCBP1-NCBP2-RAN-PHAX-XPO1)
Ohno et al., Cell 2000*
-
IRef Corum Interaction:
Complex of XPO1-SNUPN-RAN
(association, pull down)
Paraskeva et al., J Cell Biol 1999*
-
IRef Corum Interaction:
Complex of 11 proteins
(association, electrophoretic mobility shift assay)
Ohno et al., Cell 2000*
-
IRef Hprd Interaction:
Complex of 26 proteins
(in vivo)
Ohno et al., Cell 2000*, Boulon et al., Mol Cell 2004*
-
IRef Hprd Interaction:
RAN
—
XPO1
(in vitro)
Fornerod et al., Cell 1997*
-
IRef Intact Interaction:
Complex of NUP88-XPO1-RAN
(physical association, tandem affinity purification)
Hutchins et al., Science 2010
-
IRef Intact Interaction:
Complex of RAE1-NUP98-OGT-NUP188-RAN-NUP88-XPO1-PKM-NUP93
(physical association, tandem affinity purification)
Hutchins et al., Science 2010
-
IRef Ophid Interaction:
RAN
—
XPO1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Kuersten et al., Mol Cell Biol 2002
:
Steady-state nuclear localization of
exportin-t involves
RanGTP binding and two distinct nuclear pore complex interaction domains
Bohnsack et al., RNA 2004
:
Export is sensitive to depletion of nuclear RanGTP and, according to this criterion, mediated by a
RanGTP dependent
exportin
Kahle et al., J Biol Chem 2009
:
Ran dependent binding of the nuclear export receptor
Crm1/exportin 1 confirmed the presence of a leucine-rich nuclear export signal (NES) in NC2beta
Kutay et al., Mol Cell 1998
:
RanGTP regulates the
substrate-exportin-t interaction such that tRNA can be preferentially bound in the nucleus and released in the cytoplasm